The Effects of Zolpidem and Triazolam, Rilmazafone Hydrochloride on The Physical and Cognitive Functions in Healthy, Elderly Persons

唑吡坦和三唑仑、盐酸利马扎丰对健康老年人身体和认知功能的影响

• 批准号: 20500438
• 负责人: ITO Sachiko
• 金额: $ 3.16万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500438/
• 关键词: 薬剤反応性; 臨床; 脳・神経; 老化; 医療・福祉

Many problems have been reported on the use of hypnotics on the elderly, such as balance disorders, falling, and memory disorders. A safer use of hypnotics is being anticipated. We investigate the effects of a single dose of Zolpidem and Triazolam, Rilmazafone hydrochloride on the physical and cognitive function in healthy, elderly persons. We performed a double-blind crossover trial on 14 healthy elderly subjects (mean age 64.5 years) in order to investigate the residual effect of a single administration of Zolpidem (5mg) and Triazolam(0.125g), Rilmazafone hydrochloride(1mg). The subjects were given either hypnotics or a placebo at 11PM before going to bed. Objective assessments were conducted at 10PM before the subjects took the hypnotic, and at 4, 6, 10AM and 2PM the next day.The result of the Total Sway Pass was that Rilmazafone was significantly better than those of the placebo. However the results of Rilmazafone was not as good for the CFF and TUG, memory test than those of place … More bo and Zolpidem. The FRT results of Zolpidem and Triazolam were significantly better than those of the placebo. Triazolam showed little effect on the cognitive functions and the sleepiness of the subjects the day after hypnotic administration.It is known that clinical parameters which focus on the 'dynamic balance' are more useful than those which focus on 'statistic balance' in order to evaluate the accidental falls in the elderly. This study suggests that Rilmazafone hydrochloride may increase the risk of falling down because both hypnotics cause the lost of 'dynamic balance'.However, the feeling of Rilmazafone medication was not good for subjective feelings than that of a placebo. These effects may be due to Rilmazafone hydrochloride's long half- life. Therefore, subjects feel sleepiness early the next morning. It may have a good affect for the people who have interrupted sleep and early morning awakenings. Zolpidem and Triazolam have a hypnotic activity without disturbing objective and subjective performance on the following day when given to healthy elders. Less

据报道，催眠药在老年人中的使用存在许多问题，如平衡障碍、摔倒和记忆障碍。人们期待着更安全地使用催眠药。我们研究了单剂量唑吡坦和三唑仑、利马扎丰对健康老年人身体和认知功能的影响。我们对14名健康老年受试者(平均年龄64.5岁)进行了双盲交叉试验，以观察单次口服唑吡坦(5 Mg)、三唑仑(0.125g)、盐酸利马扎酮(1 Mg)的残余效应。受试者在晚上11点睡觉前被给予催眠药或安慰剂。在服用催眠药前的晚上10点，以及第二天的4点、6点、10点和2点进行客观评估。总摇摆通过的结果是利马扎酮明显优于安慰剂。然而，利马扎酮在CFF和TUG记忆测试中的效果不如Place…更多的波和唑吡坦。唑吡坦和三唑仑的FRT结果明显好于安慰剂。三唑仑在催眠后第二天对受试者的认知功能和嗜睡感几乎没有影响。众所周知，为了评估老年人意外跌倒的情况，关注动态平衡的临床参数比关注统计平衡的临床参数更有用。这项研究表明，盐酸利马扎酮可能会增加摔倒的风险，因为这两种催眠药都会导致“动态平衡”的丧失。然而，利马扎丰的药物对主观感觉的改善不如安慰剂。这些影响可能是由于盐酸利马扎酮的半衰期较长所致。因此，受试者第二天一大早就会感到困倦。它可能对那些扰乱睡眠和清晨醒来的人有好的影响。唑吡坦和三唑仑在第二天给健康老年人服用时，具有催眠活性，不会干扰客观和主观表现。较少

项目成果

The Assessment of Physical Motor Functions And Arousal Level After Awakening From An Early Morning 4:00 Till Afternoon 14:00.

清晨 4:00 至下午 14:00 醒来后身体运动功能和唤醒水平的评估。

• 发表时间: 2010
• 期刊: SLEEP
• 影响因子: 5.6
• 作者: Wakasa M;Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

The Effects of Zolpidem on Psychomotor and Subjective Evaluation in Healthy Elderly Persons.

唑吡坦对健康老年人精神运动和主观评价的影响。

• 发表时间: 2009
• 期刊: SLEEP 32
• 作者: Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

早朝起床直後における覚醒度と身体運動機能評価

清晨醒来后立即进行觉醒水平和身体运动功能评估

• 发表时间: 2011
• 期刊: 総合リハ 39(5)
• 作者: 若狭正彦;上村佐知子;大澤諭樹彦;佐々木誠
• 通讯作者: 佐々木誠

The Effects of Zolpidem and Triazolam, Rilmazafone Hydrochloride on The Physical and Cognitive Functions in Healthy, Elderly Persons.

唑吡坦和三唑仑、盐酸利马扎丰对健康老年人身体和认知功能的影响。

• 发表时间: 2010
• 期刊: SLEEP33
• 作者: Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

The Effects of Zolpidem on Phychomotor and Subjective Evaluation in Healty Elderly Persons.

唑吡坦对健康老年人运动运动和主观评价的影响。

• 发表时间: 2009
• 期刊: SLEEP32
• 作者: Ito S U;Wakasa M;Osawa Y;Shimizu K;Ito W;Aizawa R;Satake M;Shindo S;Kanbayashi T;Shimizu T
• 通讯作者: Shimizu T