Studies of food components having anti-oxidant effects on the 'depository gene' expression and its clinical application.

具有抗氧化作用的食品成分对“沉积基因”表达的研究及其临床应用。

• 批准号: 20500619
• 负责人: IKUYAMA Shoichiro
• 金额: $ 3万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500619/
• 关键词: 生活習慣病; 補完代替医療; 健康食品; 抗酸化; 細胞内脂肪滴; 遺伝子転写調節; 遺伝子; 脂質; マイクロアレイ; 発現制御

Excessive intracellular lipid accumulation causes various diseases such as atherosclerosis, fatty liver, etc. Specific proteins as we named 'depository genes' are involved in this process. We tested effects of an extract of French maritime pine, a widely used dietary supplement, on the expression of these genes in macrophages and liver cells. The compound suppressed the gene expression and lipid accumulation in both cells by different molecular mechanisms. We also analyzed the change in mRNA expression in white blood cells before and after ingestion of this compound using DNA microarray analysis. We identified 12 increased and 64 decreased genes, although physiological significance remains to be clarified at this moment.

细胞内脂质的过度积累会引起动脉粥样硬化、脂肪肝等多种疾病，而在这一过程中有一些特定的蛋白质参与其中，我们称之为“储存基因”。我们测试了法国海洋松提取物（一种广泛使用的膳食补充剂）对巨噬细胞和肝细胞中这些基因表达的影响。该化合物通过不同的分子机制抑制两种细胞中的基因表达和脂质积累。我们还使用DNA微阵列分析分析了摄入该化合物前后白色血细胞中mRNA表达的变化。我们确定了12个增加和64个减少的基因，虽然生理意义仍有待澄清。

项目成果

Function of Adipose Differentiation-Related Protein(ADRP)in Myocardial Steatosis

脂肪分化相关蛋白(ADRP)在心肌脂肪变性中的作用

• 发表时间: 2010
• 作者: Suzuki J;Ueno M;Kimura T;Imagawa M;Zenimaru Y;Takahashi S;Ikuyama S;Kraemer FB;Miyamori I
• 通讯作者: Miyamori I

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Dietary supplement use in patients with rheumatoid arthritis in Japan

日本类风湿关节炎患者的膳食补充剂使用情况

• 发表时间: 2009
• 期刊: Current Rheumatology Reviews 5
• 作者: Ikuyama S;Imamura E.
• 通讯作者: Imamura E.

Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells

• DOI: 10.1152/ajpendo.00119.2009
• 发表时间: 2009-07-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
• 影响因子: 5.1
• 作者: Fan, Bin;Ikuyama, Shoichiro;Nishimura, Junji
• 通讯作者: Nishimura, Junji

心筋 Adipose differentiation-related protein(ADRP)の機能

心肌脂肪分化相关蛋白（ADRP）的功能

• 发表时间: 2009
• 作者: 鈴木仁弥;上野勝巳;木村朋子;今川美智子;銭丸康夫;高橋貞夫;生山祥一郎;宮森勇
• 通讯作者: 宮森勇