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The mechanisms of fish oil effects on improvement of glucose and lipid metabolism and fatty liver

鱼油改善糖脂代谢及脂肪肝的作用机制

基本信息

批准号：
20500626
负责人：
KASONO Keizo
金额：
$ 3万
依托单位：
Josai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

(1)Fish oil suppresses weight gain and fat accumulation in the liver on weight rebound.We investigated the effect of fish oil on weight rebound in KK-Ay mice. The experiments suggest that fish oil suppresses body weight gain and fat accumulation in the liver on the weight rebound phase in mice. Suppression of fat accumulation in the liver is attributed to inhibition of fatty acid synthesis, enhancement of lipolysis and fatty acid oxidation, and normalization of lipoprotein secretion from the liver.(2)Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.The experiments suggest that fish oil decreases lipid levels in plasma and liver via PPARs (PPAR-α and PPAR-γ)pathway-independent mechanism, and that glucose tolerance is inversely regulated by PPARs antagonists under diets containing different oils.(3)Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver an … More d white adipose tissue.We used hydrogenated fish oil, which has saturated fatty acids with the same carbon chain lengths as the unsaturated fatty acids in fish oil, to clarify the functions of these unsaturated fatty acids on the improvements in lipid and glucose metabolism in mice. Our results indicate that unsaturated fatty acids in the FO diet decrease lipid levels in the liver and maintain the balance of lipid levels in plasma, liver and white adipose tissue. In addition, these results also suggest that C16:1 and C18:1 synthesized in the liver and white adipose tissue may improve glucose tolerance and lipid metabolism in the HFO group.(4)Regulation of lipid metabolism by palmitoleate and eicosapentaenoic acid (EPA) in mice fed a high-fat diet.We investigated whether oral administration of palmitoleate improves disorders of lipid and glucose metabolism in mice fed a high-fat diet to clarify the effects of one of the main components of fish oil. This study suggests that orally administered palmitoleate or EPA at relatively low levels improve lipid metabolism impaired with a lard-rich diet. We found that palmitoleate, as a component of fish oil, as well as EPA plays a pivotal role in improving lipid metabolism. Less

（1）鱼油抑制体重增加和肝脏中的脂肪积累对体重反弹的影响我们研究了鱼油对KK-Ay小鼠体重反弹的影响。实验表明，鱼油抑制小鼠体重反弹阶段的体重增加和肝脏中的脂肪积累。抑制肝脏中的脂肪积累归因于抑制脂肪酸合成、促进脂解和脂肪酸氧化以及使肝脏的脂蛋白分泌正常化。（2）鱼油对饮食诱导肥胖小鼠糖脂代谢的影响：鱼油通过不依赖于过氧化物酶体增殖物激活受体（PPARs）途径的机制降低血浆和肝脏中的脂质水平，不同油脂饮食诱导的肥胖小鼠糖耐量受PPARs拮抗剂的负向调节。（3）鱼油中的不饱和脂肪酸在脂肪充分分布到血浆、肝脏和肝脏中起作用。 ...更多信息 d白色脂肪组织。我们使用氢化鱼油，其具有与鱼油中的不饱和脂肪酸相同碳链长度的饱和脂肪酸，以阐明这些不饱和脂肪酸对改善小鼠脂质和葡萄糖代谢的功能。我们的研究结果表明，FO饮食中的不饱和脂肪酸降低肝脏中的脂质水平，并维持血浆、肝脏和白色脂肪组织中脂质水平的平衡。此外，这些结果还表明，C16：1和C18：1在肝脏和白色脂肪组织中合成可能改善HFO组的糖耐量和脂质代谢。（4）棕榈油酸酯和二十碳五烯酸（EPA）对高脂饮食小鼠脂质代谢的调节为了明确鱼油的主要成分之一的效果，我们研究了口服棕榈油酸酯是否能改善高脂饮食小鼠的脂质和葡萄糖代谢紊乱。这项研究表明，口服棕榈油酸酯或EPA在相对较低的水平，改善脂质代谢受损的猪油丰富的饮食。我们发现，棕榈油酸酯，作为鱼油的一个组成部分，以及EPA在改善脂质代谢中起着关键作用。少