Amelioration of tumor susceptibility by lifestyle modification in Snark-knockout mice

SNARK （SNF1/ ampk相关激酶）缺陷小鼠表现出代谢紊乱。据报道，调节全身能量消耗的IL-6在这些小鼠中含量很低。自愿运动可恢复血清IL-6水平并改善代谢紊乱。snark缺陷小鼠也表现出增加的致癌物诱导的结直肠肿瘤发生。重组IL-6和自愿运动均可显著降低肿瘤易感性。这些结果提示，恢复全身IL-6水平抑制了snark缺陷小鼠的肿瘤发生，并提示肿瘤发生与全身代谢紊乱并存。

SNARK (SNF1/AMPK-related kinase)-deficient mice exhibit metabolic disorders. IL-6, which has been reported to regulate whole body energy expenditure, was low in these mice. Voluntary exercise restored serum IL-6 level and ameliorated metabolic disorders. Snark-deficient mice also exhibited increased carcinogen-induced colorectal tumorigenesity. Both administration of recombinant IL-6 and voluntary exercise significantly reduced the tumor susceptibility. These findings imply that the restoration of systemic IL-6 level suppressed the tumorigenesity of Snark-deficient mice and the concomitance of tumorigenesis and systemic metabolic disorders were suggested.