Basic and Epidemiological study for the carcinogenic role of obesity and nutritional factors in breast and colon cancers

肥胖和营养因素对乳腺癌和结肠癌致癌作用的基础和流行病学研究

• 批准号: 20500734
• 负责人: NAKANO Shuji
• 金额: $ 2.91万
• 依托单位: Nakamura Gakuen College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500734/
• 关键词: 乳癌; 癌の一次予防; 食事性因子; 大豆イソフラボン; 肥満; アディポカイン; シグナル伝達; 症例対照研究; 乳がん; クルクミン; ゲニステイン(大豆イソフラボン); 乳がん細胞受容体状態; 乳がん一次予防; 食事調査; 植物性脂質; 健康と食生活; 大腸がん

Incidence of breast and colon cancer is increasing recently among Japanese women. As these cancers are considered to be obesity- and diet-linked diseases, we have investigated the association of breast carcinogenesis with visceral fat obesity and dietary factors through in vivo, in vitro, and epidemiological approaches. Model rats for visceral obesity did not produce any tumor 40 weeks after oral administration of ethylmethane sulphonate (EMS), while a control rats produced tumors in 2 rats out of 16 rats. Genistein (GEN), a phytochemical with weak estrogenic activity, did not suppress the incidence of EMS-induced hormone-dependent tumor in WKA rats fed on diets with low to high concentrations of GEN. A case-control study suggests that intakes of oil and plant lipids were associated with elevated risk for breast cancer, but not with Soybean intake in postmenopausal Japanese women. These results suggest that Soybean isoflavone may not reduce the risk of breast cancer for postmenopausal women.

最近，日本女性中乳腺癌和结肠癌的发病率正在上升。由于这些癌症被认为是与肥胖和饮食相关的疾病，我们通过体内、体外和流行病学的方法研究了乳腺癌的发生与内脏脂肪肥胖和饮食因素的关系。内脏肥胖模型大鼠口服乙基甲烷磺酸盐(EMS)40周后未见肿瘤形成，而对照组16只大鼠中有2只发生肿瘤。金雀异黄素(Genistein，GEN)是一种具有弱雌激素活性的植物化学物质，但不能抑制以低到高浓度Gen喂养的WKA大鼠EMS诱导的激素依赖性肿瘤的发生率。一项病例对照研究表明，在绝经后的日本女性中，油脂和植物脂肪的摄入与乳腺癌风险的增加有关，但与大豆的摄入量无关。这些结果表明，大豆异黄酮可能不会降低绝经后女性患乳腺癌的风险。

项目成果

Oxaliplatin-induced allergic reaction in patients with colorectal cancer in Japan

• DOI: 10.1007/s10147-009-0883-6
• 发表时间: 2009-10-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Shibata, Yoshihiro;Ariyama, Hiroshi;Nakano, Shuji
• 通讯作者: Nakano, Shuji

NSTガイドブック2011改訂第3版,食欲不振

NST 指南 2011 年修订版第 3 版，厌食症

• 发表时间: 2011
• 作者: Abe Y;Ito T;Baba E;Nagafuji K;Kawabe K;Choi I;Arita Y;Miyamoto T;Teshima T;Nakano S;Harada M;Shibata Y;牧山明資;Moriyama K;八住香代子;小野美咲
• 通讯作者: 小野美咲

NSTガイドブック2011改訂第3版(食欲不振)

NST 指南 2011 年修订版第 3 版（厌食症）

• 发表时间: 2011
• 作者: Abe Y;Ito T;Baba E;Nagafuji K;Kawabe K;Choi I;Arita Y;Miyamoto T;Teshima T;Nakano S;Harada M;Shibata Y;牧山明資;Moriyama K;八住香代子;小野美咲;小野美咲
• 通讯作者: 小野美咲

RASのシグナル伝達機構と阻害剤

RAS信号机制及抑制剂

• 发表时间: 2009
• 期刊: Mebio 26
• 作者: Abe Y;Ito T;Baba E;Nagafuji K;Kawabe K;Choi I;Arita Y;Miyamoto T;Teshima T;Nakano S;Harada M;Shibata Y;牧山明資
• 通讯作者: 牧山明資

Polymerase chain reaction detection of bacterial 16S rRNA gene in human blood

• DOI: 10.1111/j.1348-0421.2008.00048.x
• 发表时间: 2008-07-01
• 期刊: MICROBIOLOGY AND IMMUNOLOGY
• 影响因子: 2.6
• 作者: Moriyama, Kosei;Ando, Chie;Hirakawa, Hideki
• 通讯作者: Hirakawa, Hideki