The development of novel bioactive compounds from the nematocysts.
The development of novel bioactive compounds from the nematocysts.
批准号:
20510197
负责人:
NAGAI Hiroshi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The screening of the novel bioactive compounds were accomplished on some cnidarians and isolated nematocysts. We have succeeded in the isolation and characterization of some new bioactive proteins and small molecular weight compounds. A new actinoporin toxin was isolated and characterized from the sea anemone Anthopleura asiatica. Furthermore, a new Kunitz type protease inhibitor protein was characterized from the sea anemone Phyllodiscus semoni.
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Role of the phenolic hydroxyl group in the biological activities of simplyfied analogue of aplysiatoxin with antiproliferative activity.
酚羟基在具有抗增殖活性的海兔毒素简化类似物的生物活性中的作用。
DOI:
--
发表时间:
2010
期刊:
Bioorganic & Medicinal Chemistry Letters
影响因子:
2.7
作者:
[R.C.Yanagita, H.Kamachi, K.Tanaka, A.Murakami, Y.Nakagawa, H.Tokuda, H, Nagai, K.Irie]
通讯作者:
K.Irie
Structural characterization of plancitoxin I, a deoxyribonucleases II-like lethal factor from the crown-of-thorns starfish Acanthaster planci, by expression in Chinese hamster ovary cells
通过在中国仓鼠卵巢细胞中的表达来表征来自棘冠海星 Acanthaster planci 的 Plancitoxin I(一种脱氧核糖核酸酶 II 样致死因子)的结构特征
DOI:
--
发表时间:
2009
期刊:
Fisheries Science 75
影响因子:
--
作者:
[Ai Watanabe, Hiroshi Nagai, Yuji Nagashima A, Kazuo Shiomi]
通讯作者:
Kazuo Shiomi
クラゲの毒
水母毒
DOI:
--
发表时间:
2009
期刊:
科学(岩波書店) 79
影响因子:
--
作者:
[金子謙佑, 岡部佳弘, 浅水恵理香, 江面浩, 永田典子, 加藤雅也, 本橋令子, 永井宏史]
通讯作者:
永井宏史
Purification and Seaching for Bioactive Water-Soluble Compounds from Marine Sponges.
从海洋海绵中纯化和寻找生物活性水溶性化合物。
DOI:
--
发表时间:
2008
期刊:
Proceedings of the WFC2008 (5th World Fisheries Congress) 3g-0678-483 (CD)
影响因子:
--
作者:
[Kosaku Ito, Atsushi Tsuruta, Keiji Takahara, Satoko Matayoshi, Hiroshi Nagai.]
通讯作者:
Hiroshi Nagai.
ハブクラゲ刺胞に局在する低分子化合物の探索
寻找水母刺丝囊中的低分子量化合物
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[本橋令子, 鈴木美穂, 高橋祥子, 道羅英夫, 切岩祥和, 藤原正幸, 深尾陽一郎, 永田典子, 北谷龍樹・内田肇・鈴木敏之・長島裕二・神尾道也・永井宏史]
通讯作者:
北谷龍樹・内田肇・鈴木敏之・長島裕二・神尾道也・永井宏史
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