Cortico-collicular pathways for the modulation of innate behaviour and their roles in learning

调节先天行为的皮质-丘脑通路及其在学习中的作用

• 批准号: 537190522
• 负责人: Professor Dr. Alexander Groh, Ph.D.
• 金额: --
• 依托单位: Institut für Physiologie und Pathophysiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/537190522?language=en
• 关键词: Cortico; collicular; pathways; modulation; innate

This proposal aims to investigate the role of cortical pathways in modulating innate somatosensory behaviours mediated by the superior colliculus (SC) in mice. The central hypothesis is that cortical layer 5 inputs to the whisker SC can enhance or suppress innate behavioural responses to whisker stimuli, providing a mechanism for behavioural flexibility. The study will also explore the involvement of cortico-collicular pathways in learning and whether these connections can be modified through Hebbian plasticity mechanisms to generate long-lasting changes in innate behaviour. The project will utilize a newly established whisker stimulation paradigm to study SC-dependent startle responses and employ optogenetic techniques to target specific populations of cortex-recipient neurons in the SC. The findings from this study will contribute to our understanding of the neural mechanisms underlying innate behaviours and their modulation by cortical inputs, as well as shed light on the question of synaptic plasticity mechanisms in neuronal circuits for innate behaviours.

本研究旨在探讨小鼠大脑皮层通路在调节上级丘（SC）介导的先天性躯体感觉行为中的作用。中心假设是，皮质层5输入的胡须SC可以增强或抑制先天的行为反应，胡须刺激，提供了一种机制的行为灵活性。该研究还将探讨皮质-丘途径在学习中的参与，以及这些连接是否可以通过赫布可塑性机制进行修改，以产生先天行为的长期变化。该项目将利用新建立的胡须刺激范式来研究SC依赖性惊吓反应，并采用光遗传学技术来靶向SC中特定的皮质受体神经元群体。这项研究的结果将有助于我们理解先天行为背后的神经机制及其通过皮质输入的调节，以及阐明先天行为的神经元回路中突触可塑性机制的问题。