Corticothalamic ensembles for multimodal salience coding

用于多模态显着性编码的皮质丘脑系综

• 批准号: 438790705
• 负责人: Professor Dr. Alexander Groh, Ph.D.
• 金额: --
• 依托单位: Institut für Anatomie und Zellbiologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/438790705?language=en
• 关键词: Corticothalamic; ensembles; multimodal; salience; coding

This project investigates how behavioural functions are computed by putative neuronal ensembles in the sensory thalamus of mice. Building on our preliminary observations that sensory representations in the thalamus are context-dependent and multimodal, we will use electrophysiological and imaging approaches to study ensemble generation during simple yet natural behaviours, such as whisking and locomotion. In an object examination paradigm, we will test the hypothesis that thalamic ensembles represent perceptual stimulus salience. Finally, we will test the causal involvement of corticothalamic interactions in thalamic ensemble recruitment. Overall, we expect a better understanding of context-dependent sensory processing.

该项目研究了小鼠的感觉丘脑中推定的神经元合奏如何计算行为函数。在我们初步观察的基础上，丘脑中的感官表示是上下文依赖性和多模式的，我们将使用电生理学和成像方法来研究简单而自然的行为（例如鞭打和运动）期间的整体产生。在对象检查范式中，我们将检验以下假设：丘脑合奏代表感知刺激的显着性。最后，我们将测试丘脑合奏招募中皮质丘脑相互作用的因果关系。总体而言，我们希望更好地理解与上下文有关的感觉处理。