Catalytic Generation of Chiral Silicon Enolates : Development of Direct Asymmetric Catalytic Reaction

手性刘易斯酸与酮反应生成的烯醇化硅催化剂存在下，对甲苯磺酰亚胺与酮的Mannich反应顺利进行，得到了相应的Mannich加成物，其对映体过量值为1.5。在硅刘易斯酸催化下，β，γ-不饱和γ-内酰胺与对甲苯磺酰亚胺反应，以中等产率得到4，5-二取代γ-内酰胺。该反应最显著的特点是原子经济性高。

Mannich reaction between tosylimines and ketones smoothly took place in the presence of chiral silicon enolates, which were catalytically generated from the reaction of chiral Lewis acids with ketones, giving the corresponding Mannich adducts with moderate enantiomeric excess. In the presence of silicon Lewis acid catalysis,β,γ-unsaturatedγ-ractams react with tosylimines to afford 4, 5-disubstitutedγ-lactam in moderate yields. The most striking characteristic of this reaction is high atom economy.