Interaction between BDNF and polysialic acid localized in brains
Interaction between BDNF and polysialic acid localized in brains
批准号:
20570107
负责人:
SATO Chihiro
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Polysialic acid (polySia) is the anionic polysaccharide expressed mainly in vertebrate brains. PolySia modifies embryonic NCAM and functions as a negative regulator between cell-cell/extracellular matrix via its bulky and exclusive features. In this study, we demonstrated that polySia directly binds to a brain derived neurotrophic factor (BDNF) and that through its interaction it regulates the ligand-receptor interactions.
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原索動物由来CMP-シアル酸合成酵素の性質
原索动物衍生的 CMP-唾液酸合酶的特性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[藤田明子, 安川裕子, 佐藤ちひろ, 澤田均, 窪川かおる, Guerardel Yann, 北島健]
通讯作者:
北島健
Demonstration of the presence of triSia-containing glycoproteins in mouse developing brain by the triSia structure-specific monoclonal antibody A2B5
通过 triSia 结构特异性单克隆抗体 A2B5 证明小鼠发育大脑中存在含有 triSia 的糖蛋白
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Emi Inoko, Hiroshi Tanaka, Takashi Takahashi, Koichi Furukawa, Ken Kitajima, Chihiro Sato]
通讯作者:
Chihiro Sato
Investigation of evolutionarily conserved CMP-sialic acid synthetases for Sia species from prochordate.
前索动物 Sia 物种进化上保守的 CMP-唾液酸合成酶的研究。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Akiko Fujita, Yuko Yasukawa, Chihiro Sato, Ken Kitajima]
通讯作者:
Ken Kitajima
CMP-シアル酸合成酵素のCMP-KDN合成能の構造的基盤
CMP-唾液酸合酶 CMP-KDN 合成能力的结构基础
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[藤由明子, 他]
通讯作者:
他
A new function of polysialic acid on NCAM as the reservoir for the particular groups of neurotrophins, growth factors, and neurotransmitters that regulate the neural activity.
聚唾液酸在 NCAM 上的新功能是作为调节神经活动的特定神经营养素、生长因子和神经递质组的储存库。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ken Kitajima, Yukihiro Kanato, Ryo Isomura, Sayaka Ono, Chihiro Sato]
通讯作者:
Chihiro Sato
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A Study on the Qualitative Transformation of Educational Discourse by the Mass Media in the around 1970s
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批准号:17K04596
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2017
-
负责人:SATO Chihiro
-
依托单位:
Molecular mechanism of new cellular functions mediated by polysialic acid
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批准号:15K06995
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.16万
-
财政年份:2015
-
负责人:SATO Chihiro
-
依托单位:
Regulation of neural functions via polySia and FGF2 interaction
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批准号:23570133
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2011
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负责人:SATO Chihiro
-
依托单位:
海外基金