Modulation of interferon action by intrinsic galectin-9 in cultured human endothelial cells.

利用半乳糖凝集素-9的siRNA敲除实验表明，在培养的人内皮细胞中，内源性半乳糖凝集素-9调节IFN的作用。然而，使用新一代sirna的验证实验表明，这种观察结果是由于老一代sirna的脱靶效应。去年进行的实验表明半乳糖凝集素-9与人内皮细胞内质网应激（ER应激）之间的关系。我正在继续研究半乳糖凝集素-9在内皮细胞中与内质网应激有关的作用。

Knockdown experiments using siRNA of galectin-9 suggested that intrinsic galectin-9 modulates IFN action in cultured human endothelial cells. Confirmation experiments using new-generation siRNAs, however, demonstrated that the observation was due to the off-target effects of old-generation siRNAs. The experiments carried out on the last year suggested the relationship between galectin-9 and endoplasmic reticulum stress (ER stress) in human endothelial cells. I am continuing to investigate the role of galectin-9 in endothelial cells in relation to ER stress.