The Interactive Mechanisms of neural cell adhesion molecules ; Protocadherin and IgCAM.

免疫球蛋白超家族细胞粘附分子（IgCAM）和原钙粘蛋白家族成员（Pcdh）在神经网络的形成中起着重要作用。这些成员蛋白不仅与各种细胞粘附蛋白，而且与许多细胞外蛋白（ecm）具有亲血性结合和异亲性结合的相互作用系统。硫酸软骨素蛋白聚糖的表达对IgCAMs和Pcdh的调控作用尤为明显。我们产生了参与硫酸软骨素合成的酶的敲除小鼠。IgCAMs和Pcdh的表达模式在脑形成的发育阶段受到干扰。

Immunoglobulin superfamily cell adhesion molecules (IgCAM) and Proto-cadherin family members (Pcdh) play important roles in the neural network formations. These member proteins have the interaction systems of hemophilic binding and heterophilic bindings to not only various cell adhesion proteins but also many extra cellular proteins (ECMs). IgCAMs and Pcdh were regulated by the expression of chondroitin sulfate proteoglycans especially. We generated the knockout mice of the enzymes involved in the synthesizing of chondroitin sulfate. The expression pattern of IgCAMs and Pcdh were perturbed in the developmental stages of brain formation.