The Interactive Mechanisms of neural cell adhesion molecules ; Protocadherin and IgCAM.
The Interactive Mechanisms of neural cell adhesion molecules ; Protocadherin and IgCAM.
批准号:
20570187
负责人:
TAKEUCHI Kosei
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Immunoglobulin superfamily cell adhesion molecules (IgCAM) and Proto-cadherin family members (Pcdh) play important roles in the neural network formations. These member proteins have the interaction systems of hemophilic binding and heterophilic bindings to not only various cell adhesion proteins but also many extra cellular proteins (ECMs). IgCAMs and Pcdh were regulated by the expression of chondroitin sulfate proteoglycans especially. We generated the knockout mice of the enzymes involved in the synthesizing of chondroitin sulfate. The expression pattern of IgCAMs and Pcdh were perturbed in the developmental stages of brain formation.
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DOI:
10.1073/pnas.0904092106
发表时间:
2009-10-06
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Nozumi, Motohiro, Togano, Tetsuya, Igarashi, Michihiro]
通讯作者:
Igarashi, Michihiro
DOI:
10.1016/j.neures.2011.01.006
发表时间:
2011-05-01
期刊:
NEUROSCIENCE RESEARCH
影响因子:
2.9
作者:
[Lu, Jia, Nozumi, Motohiro, Igarashi, Michihiro]
通讯作者:
Igarashi, Michihiro
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Tai PT, Nishijo M, Nakagawa H, Maruzeni S, Anh NTN, Luong HV, Anh TH, Morikawa Y, Kido T, Nishijo H., Takeuchi K. et. Al]
通讯作者:
Takeuchi K. et. Al
コンドロイチン硫酸合成酵素欠損マウスにおける脳発達異常
硫酸软骨素合酶缺陷小鼠大脑发育异常
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[比嘉進, 他(7人中7番目)]
通讯作者:
他(7人中7番目)
細胞外基質コンドロイチン硫酸は如何に神経発生・神経再生に機能するか
细胞外基质硫酸软骨素在神经发生和神经再生中如何发挥作用?
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nishimura K, et. al., 武内恒成]
通讯作者:
武内恒成
共 19 条
Regulation of the chondroitin sulfate and recovery systems from the spinal cord injury.
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批准号:23592161
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:TAKEUCHI Kosei
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依托单位:
海外基金