Translational regulation by mRNA granules in cell proliferation, stress response and neuronal network formation

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mRNA transport and subsequent local translation in neuronal dendrites play key roles in synaptic long-term plasticity and also in learning and memory. They are mediated by mRNA granules, macromolecular complexes containing their cargo mRNAs. Here we identified target mRNAs for RNG105, a component of mRNA granules in neurons. We found that the target mRNAs were transported to dendrites in an RNG105-dependent manner. But translational regulation of mRNAs did not appear to be mediated by RNG105 but other unidentified factors. We also showed that in proliferating cells, RNG105 was localized to stress-induced stress granules in which translation of mRNAs were repressed.