Analyses of the fine-tuning mechanism of Arf6 activity on reorganization of epithelial organ

ARF6先前被认为在上皮性癌的侵袭中起关键作用。在本研究中，一种位于Arf6上游的硫酸软骨素蛋白多糖NG2可能参与了胶质瘤的侵袭。此外，钠离子/质子交换器1(NHE-1)介导的信号在胶质瘤细胞侵袭中起关键作用，而不依赖于Arf6信号。这些结果表明，同时抑制这两种信号可作为脑胶质瘤抗侵袭治疗的有效方案。

Arf6 was previously proposed to be critical for epithelial cancer invasion. In this study, possible participation of one of the chondroitin sulfate proteoglycan NG2 at the upstream of Arf6 in glioma invasion was presented. Moreover, a signal mediated by sodium ion/proton exchanger 1 (NHE-1) was found to play a pivotal role in glioma cell invasion, independently of the Arf6 signal. These results implicate simultaneous inhibition of the both signals as effective therapeutic protocol for anti-invasion therapy of glioma.