Molecular mechanism of biological timer-determination mechanism of pupation timing of Drosophila-

生物定时器的分子机制——果蝇化蛹时机的决定机制——

• 批准号: 20570204
• 负责人: UEDA Hitoshi
• 金额: $ 3.16万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570204/
• 关键词: 発生; ショウジョウバエ; タイミング; タイマー; エクダイソン; 蛹化

We uncovered mechanism to determine the termination of Blimp-1 expression which is important to determine the pupation timing in Drosophila. We also found that expression level and stability of Blimp-1 are important factor to determine the pupation timing and Blimp-1 works as sands in hourglass. Furthermore, we found that this timer system proceeds almost the same speed in different organs, but the speed is slightly different depending organs.

我们揭示了果蝇Blimp-1表达终止的机制，这对果蝇化蛹时间的确定具有重要意义。我们还发现Blimp-1的表达水平和稳定性是决定化蛹时间的重要因素，Blimp-1在沙漏中起着沙子的作用。此外，我们发现该定时器系统在不同器官中的运行速度几乎相同，但不同器官的运行速度略有不同。

项目成果

Stability of transcription factor Blimp-1 plays a crucial role in determining developmental timing at the onset of metamorphosis in Drosophila

转录因子Blimp-1的稳定性在果蝇变态开始时的发育时间决定中起着至关重要的作用

• 发表时间: 2008
• 作者: Hitoshi Ueda;Moustafa Sarhan;Kazutaka Akagi
• 通讯作者: Kazutaka Akagi

Regulatory mechanisms of ecdysone-inducible Blimp-1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila

• DOI: 10.1111/j.1440-169x.2011.01276.x
• 发表时间: 2011-06-01
• 期刊: DEVELOPMENT GROWTH & DIFFERENTIATION
• 影响因子: 2.5
• 作者: Akagi, Kazutaka;Ueda, Hitoshi
• 通讯作者: Ueda, Hitoshi

A transcriptional repressor Blimp-1 works as an hourglass timer during metamorphosis

转录抑制因子 Blimp-1 在变态过程中充当沙漏计时器

• 发表时间: 2010
• 作者: Kazutaka Akagi;Moustafa Sarhan;Hitoshi Ueda
• 通讯作者: Hitoshi Ueda

A transcriptional repressor Blimp-1 works as an hourglass timer during Drosophila metamorphosis

转录抑制因子 Blimp-1 在果蝇变态过程中充当沙漏计时器

• 发表时间: 2010
• 作者: Kazutaka Akagi;Moustafa Sarhan;Hitoshi Ueda
• 通讯作者: Hitoshi Ueda

Regulatory mechanism of a ecdysone primary-response gene Blimp-1, it differs from well-known early genes

蜕皮激素初级反应基因Blimp-1的调控机制，它与众所周知的早期基因不同

• 发表时间: 2009
• 作者: Kazutaka Akagi;Hitoshi Ueda
• 通讯作者: Hitoshi Ueda