Two-component membrane pore-forming toxins - The elucidation of the details of cytolysis mechanism, and its application to the cell-specific toxin molecular design-

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Staphylococcal γ-hemolysin and leukocidins are two-component hetero oligomeric pore-forming cytolytic toxins. In this study, the mode of action including cell specificity and horizontal gene transfer system of these toxins were investigated.1) Receptors for the initial components on the target cells were explored.2) The intra-molecular factor(s) involved in the opening pore was searched.3) The mechanism causing the white cell lysis and inflammation was studied.4) Novel basteriophages related to horizontal transfer of Panton Valentine leukosidin was characterized, and the phage protein which recognize host cell was identified.