Chemical Biology of lifespan-extending substrates secreted by the nematode Caenorhabditis elegans

点击翻译按钮获取中文摘要

I have identified Caenorhabditis elegans insulin-like genes ins-6, ins-12, and ins-35. Expression of these genes was regulated by lifespan-extending substances secreted by C.elegans. Gene-disruption revealed that ins-6 and ins-12 were relevant to regulation of lifespan. In contrast, ins-35 was largely relevant to regulation of larval diapause not adult lifespan. In addition, analyses of expression patterns of ins-35 allowed me to understand the physiological function of the gene.