Chemical Biology of lifespan-extending substrates secreted by the nematode Caenorhabditis elegans

我已经确定了秀丽隐杆线虫胰岛素样基因ins-6，ins-12和ins-35。这些基因的表达受到秀丽隐杆线虫分泌的延长寿命物质的调节。基因破坏表明ins-6和ins-12与寿命调节相关。相比之下，ins-35主要与幼虫滞育的调节有关，而不是成虫寿命。此外，对ins-35表达模式的分析使我了解了该基因的生理功能。

I have identified Caenorhabditis elegans insulin-like genes ins-6, ins-12, and ins-35. Expression of these genes was regulated by lifespan-extending substances secreted by C.elegans. Gene-disruption revealed that ins-6 and ins-12 were relevant to regulation of lifespan. In contrast, ins-35 was largely relevant to regulation of larval diapause not adult lifespan. In addition, analyses of expression patterns of ins-35 allowed me to understand the physiological function of the gene.