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The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease)

The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease)
开发疯牛病超灵敏诊断技术
批准号:
20580354
负责人:
YAMAGUCHI Yoshitaka
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
This research was designed to develop a ultra-sensitive detection method for prion disease. We tried to establish the detection method with high sensitivity and singularity, according to amplify the DNA which uniquely bound to the prion protein and decide the sequence. Though the DNA sequence GGATG was identified from REPSA method as a candidate of consensus sequence, it didn't support sufficient for reproducibility and specificity in the latest study.
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DOI: 10.1007/s00705-008-0086-x
发表时间: 2008-06-01
期刊: ARCHIVES OF VIROLOGY
影响因子: 2.7
作者: [Nasu-Nishimura, Y., Taniuchi, Y., Onodera, T.]
通讯作者: Onodera, T.
DOI: 10.1007/s10571-011-9696-z
发表时间: 2011-10-01
期刊: CELLULAR AND MOLECULAR NEUROBIOLOGY
影响因子: 4
作者: [Fujita, Koji, Yamaguchi, Yoshitaka, Sakaguchi, Suehiro]
通讯作者: Sakaguchi, Suehiro
Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like rotein/doppel in mice.
朊病毒蛋白 N 末端一半对小鼠中朊病毒蛋白样蛋白/二元神经毒性的显性负效应。
DOI: --
发表时间: 2008
期刊: J Biol Chem. 283(35)
影响因子: --
作者: [Yoshikawa D, Yamaguchi N, Ishibashi D, Yamanaka H, Okimura N, Yamaguchi Y, Mori T, Miyata H, Shigematsu K, Katamine S, Sakaguchi S.]
通讯作者: Sakaguchi S.
プリオン蛋白構造変換におけるアミノ酸911104領域の役割
氨基酸911104区域在朊病毒蛋白结构转变中的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ogiwara, K., Hata, K., 片桐成二, 佐々田純, 山口仁孝]
通讯作者: 山口仁孝
8
    The investigation for adaptive possibility of Biotic Ligand Model in Japanese sea area
    • 批准号:
      25289325
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.48万
    • 财政年份:
      2013
    • 负责人:
      YAMAGUCHI Yoshitaka
    • 依托单位:
    Development of multinuclear transition metal catalyst and hybrid-type molecular catalyst based on coordination control of N-heterocyclic carbene
    • 批准号:
      25410063
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2013
    • 负责人:
      YAMAGUCHI Yoshitaka
    • 依托单位:
    Analysis of ectopic expression of autoantigen genes using Aire+ cell lines
    • 批准号:
      21790952
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2009
    • 负责人:
      YAMAGUCHI Yoshitaka
    • 依托单位:
    Analysis of copper compounds from antifouling paints on ship hall in seawater
    • 批准号:
      21760675
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $3.0万
    • 财政年份:
      2009
    • 负责人:
      YAMAGUCHI Yoshitaka
    • 依托单位:
    海外基金