Development of rapid analysis method of drugs of abuse used for forensic science and clinical chemistry

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In this study, determination of abused drugs such as MDMA, TFMPP, and related illegal drugs, and psychoactive drugs such as benzodiazepines, methylphenidate and methamphetamine has been developed by liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS), which is able to measure accurate mass with high sensitivity and high accuracy. Furthermore, a new pretreatment method so-called solid-phase dispersive extraction (SPDE) has been also developed for sample purification. In addition, a novel apparatus named a centrifugal filtration filter unit was invented for the purpose of simple and easy operation of the SPDE method.