Production of hepatocyte growth factor (HGF) and tissue regeneration induced by natural products

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Hepatocyte growth factor (HGF) has been shown to stimulate the proliferation of epithelial cells in various tissues including hepatocytes and play critical roles in regenerative events of tissues. Here we found that the extracts of bitter melon placenta and Cordyceps sinensis and polymyxin B promoted HGF production in human fibroblasts and described their mechanism and properties of active component(s). Injection of polymyxin B to rats significantly increased both plasma and hepatic HGF levels.