Regulatory role of ezrin on transportsome at the blood placenta barrier
Regulatory role of ezrin on transportsome at the blood placenta barrier
批准号:
20590158
负责人:
SAI Yoshimichi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
This study was aimed to clarify the regulatory role of ezrin on transporter complex (transportsome) at the placenta barrier. Our study using syncytiotrophoblast cell line TR-TBTs, pregnant rats as well as knockout mice lacking ezrin, scaffold protein that links membrane proteins to the cortical actin, have suggested that ezrin is located at the apical membrane of syncytiotrophoblasts during the course of pregnancy and works as a functional regulator in the transportsome containing a hypotaurin transporter Slc6a13.
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GABA輸送担体(Slc6a13/GAT-2)を介したhypotaurineの胎盤供給機構
通过 GABA 转运蛋白 (Slc6a13/GAT-2) 的亚牛磺酸胎盘供应机制
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[樋口慧, 西村友宏, 登美斉俊, 崔吉道, 中島恵美]
通讯作者:
中島恵美
エズリン欠損マウス胎盤におけるP-糖タンパク質の機能低下
埃兹蛋白缺陷小鼠胎盘中 P-糖蛋白功能降低
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[出口雅之, 樋口 慧, 和田真実, 西村友宏, 巨勢典子, 崔 吉道, 中島恵美]
通讯作者:
中島恵美
血液-胎盤関門での2', 3'-dideoxyinosine (ddI)取り込みにおけるENT2の関与
ENT2 参与血胎盘屏障的 2, 3-双脱氧肌苷 (ddI) 摄取
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[佐藤和子, 地主拓也, 巨勢典子, 西村友宏, 崔 吉道, 中島恵美]
通讯作者:
中島恵美
DOI:
10.1007/s11095-008-9564-9
发表时间:
2008-07-01
期刊:
PHARMACEUTICAL RESEARCH
影响因子:
3.7
作者:
[Sai, Y., Nishimura, T., Nakashima, E.]
通讯作者:
Nakashima, E.
DOI:
10.1369/jhc.2008.952440
发表时间:
2009-04
期刊:
Journal of Histochemistry & Cytochemistry
影响因子:
3.2
作者:
[T. Wakayama;Hiroki Nakata;Miho Kurobo;Y. Sai;S. Iseki]
通讯作者:
T. Wakayama;Hiroki Nakata;Miho Kurobo;Y. Sai;S. Iseki
共 51 条
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批准号:19K07217
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财政年份:2011
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Clarification of xenobiotic recognition mechanism at the blood-placentabarrier by transporter array
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批准号:18590154
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资助金额:$2.57万
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财政年份:2006
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负责人:SAI Yoshimichi
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依托单位: