Improvement of exercise performance by gene therapy

通过基因疗法改善运动表现

• 批准号: 20590215
• 负责人: SAKATA Susumu
• 金额: $ 3.16万
• 依托单位: Kio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590215/
• 关键词: 遺伝子治療; SERCA2a; 不全心; 再生医学; 運動生理学; ラット; 運動パフォーマンス; SERCA

Systolic/diastolic blood pressures(BP) in aortic-banding(Band) group were lower than those in sham-operation(Sham) group 6-18 months after the operation. Likewise, endurance capacity was lower in"Band"than in"Sham"18 months after the operation. However, systolic BP and endurance capacity in"Band"could be increased by 3 week-voluntary wheel-running exercise. To conclude, these results suggest that daily light exercise is a potential strategy for improving BP and endurance capacity in patients with heart failure.

术后6-18个月，结扎组的收缩压/舒张压均低于假手术组。同样，术后18个月，“Band”组的耐力低于“Sham”组。3周自愿跑轮运动可提高“带“的收缩压和耐力。总之，这些结果表明，每日轻度运动是改善心力衰竭患者血压和耐力的潜在策略。

项目成果

Voluntary wheel running decreases blood pressure and increases endurance capacity in rats

自愿跑轮可降低大鼠的血压并提高耐力

• 发表时间: 2011
• 作者: Sakata S;Nishii Y;Hanaoka T;Ishizawa R;Iwami K;Minematsu A;Imagita H;Itou A;Waki H & Nakatani A
• 通讯作者: Waki H & Nakatani A

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Effects of different high fat diets on FABP content in rat skeletal muscles

不同高脂饮食对大鼠骨骼肌FABP含量的影响

• 发表时间: 2011
• 作者: Ishizawa R;Sakata S & Nakatani A
• 通讯作者: Sakata S & Nakatani A

Assessing myocardial systolic function : are we moving beyond the end-systolic elastance of the left ventricle?

评估心肌收缩功能：我们是否超出了左心室的收缩末期弹性？

• 发表时间: 2011
• 作者: Chemaly ER;Chaanine A;Sakata S;Hajjar RJ
• 通讯作者: Hajjar RJ

Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure

• DOI: 10.1016/j.jacc.2007.12.014
• 发表时间: 2008-03-18
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
• 影响因子: 24
• 作者: Kawase, Yoshiaki;Ly, Hung Q.;Hajar, Roger J.
• 通讯作者: Hajar, Roger J.