Sex steroids and the sexually dimorphic nucleus of the rat preoptic area

性类固醇和大鼠视前区的性二形核

• 批准号: 20590238
• 负责人: ORIKASA Chiotse
• 金额: $ 3.08万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590238/
• 关键词: 性差; エストロゲン; 神経細胞移動; 脳・神経; 細胞死; 脳; 性差形成; ステロイド; SDN-POA; BrdU; カルビンジン

Although the SDN-POA was significantly larger in males than in females at PD15, the total numbers of neurons comprising the SDN-POA were not significantly different between sexes. Sexual dimorphism in the SDN-POA results from male-specific postnatal radial spreading of cells rather than cell proliferation during embryonic neurogenesis.

虽然在PD15时，雄性的SDN-POA明显大于雌性，但构成SDN-POA的神经元总数在性别间无显著差异。SDN-POA的性别二态性是由男性特异性的出生后径向扩散的细胞引起的，而不是胚胎神经发生过程中的细胞增殖。

项目成果

Similar numbers of neurons are generated in the male and female rat preoptic area in utero

子宫内雄性和雌性大鼠视前区产生相似数量的神经元

• DOI: 10.1016/j.neures.2010.05.008
• 发表时间: 2010
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: Orikasa C;Kondo Y;Usui S;Sakuma Y
• 通讯作者: Sakuma Y

Cetrorelix, a Gonadotropin-Releasing Hormone Antagonist, Induces the Expression of Melatonin Receptor 1a in the Gonadotropin-Releasing Hormone Neuronal Cell Line GT1-7

• DOI: 10.1159/000231993
• 发表时间: 2009-01-01
• 期刊: NEUROENDOCRINOLOGY
• 影响因子: 4.1
• 作者: Ishii, Hirotaka;Sato, Shun;Kato, Masakatsu
• 通讯作者: Kato, Masakatsu

Alternative promoter usage and alternative splicing of therat estrogen receptor gene generate numerous mRNA variants with distinct 5'-ends.

雌激素受体基因的选择性启动子使用和选择性剪接产生大量具有不同5端的mRNA变体。

• 发表时间: 2010
• 期刊: JournalSteroid Biochemistry and Molecular Bioligy 118(1/2)
• 作者: Ishii H;Kobayashi M;Sakuma Y
• 通讯作者: Sakuma Y

Estrogen Receptor α Gene Promoter 0/B Usage in the Rat Sexually Dimorphic Nucleus of the Preoptic Area

• DOI: 10.1210/en.2009-1022
• 发表时间: 2010-04-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Hamada, Tomohiro;Sakuma, Yasuo
• 通讯作者: Sakuma, Yasuo

Sexual dimorphism in the preoptic area of C57Bl/6J and ddN strains of mice.

C57Bl/6J 和 ddN 品系小鼠视前区的性别二态性。

• 发表时间: 2010
• 作者: Orikasa C;Sakuma Y
• 通讯作者: Sakuma Y