The myocardial metabolic function and its control molecules in cardiac hypertrophy

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Takotsubo cardiomyopathy is an increasingly recognized clinical syndrome characterized by acute reversible apical ventricular dysfunction. We tried to make a new model of Takotsubo-like cardiomyopathy in non-human primates. Echocardiography revealed that repeated intravenous infusion of epinephrine overdose in cynomolgus monkeys induced Takotsubo-like cardiomyopathy, which is characterized by progressive left ventricle and depressed systolic function with severe hypokinesis in apical regions and hyperkinesis in the basal region. Although this cardiac dysfunction almost normalized after a month even without any treatment, metoprolol, a β-blocker, improved the decreased ejection fraction earlier than the control. This model is valuable in understanding the pathogenesis of Takotsubo cardiomyopathy and effectivity of β-blockers.