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Search of new therapeutic agents for drug dependence and analysis of the inherited difference in patients with drug dependence.

Search of new therapeutic agents for drug dependence and analysis of the inherited difference in patients with drug dependence.
药物依赖新治疗药物的寻找及药物依赖患者遗传差异分析。
批准号:
20590269
负责人:
KATSURA Masashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We investigated the detailed and new common mechanisms underling the accentuation of L-type high voltage-gated calcium channels function in establishment of psychological and physical dependence. Phosphorylation of heat shock factor and following increase in heat shock proteins 70 (HSP70) were observed in sustained ethanol-treated neuronal cells. In addition, intracellular ferrous iron concentrations were also significant increased after long-term exposure of ethanol. These results suggest the possibility that increase in intracellular HSP70 expressions and ferrous iron concentrations are new target for mechanism of drug dependence.
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会议论文
Direct evidence for the up-regulation of Vps34 regulated by PKCg during short-term treatment with morphine.
吗啡短期治疗期间 PKCg 调节的 Vps34 上调的直接证据。
DOI: --
发表时间: 2009
期刊: Synapse 63
影响因子: --
作者: [Shibasaki M, Kurokawa K, Katsura M, Ohkuma S]
通讯作者: Ohkuma S
「アルコール依存症病態発現時の神経薬理学的機序」アルコール・医学医療の最前線別冊 医学のあゆみ(竹井謙之編集)
《酒精依赖病理发生时的神经药理学机制》酒精与医疗前沿医学史专卷(武井健行主编)
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [伊勢文孝, 他, 桂 昌司]
通讯作者: 桂 昌司
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [赤木玲子, 等]
通讯作者:
DOI: 10.1002/syn.20612
发表时间: 2009-05-01
期刊: SYNAPSE
影响因子: 2.3
作者: [Shebasaki, Masahiro, Kurokawa, Kazuhiro, Ohkuma, Seitaro]
通讯作者: Ohkuma, Seitaro
17
    Study on incretin-mediated glucagon secretion in the onset and development of diabetes mellitus
    • 批准号:
      25460113
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2013
    • 负责人:
      KATSURA Masashi
    • 依托单位:
    Identification of common biological markers underlying establishment of drug dependence and an attempt to develop pharmacogenomic therapy
    • 批准号:
      18500302
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.55万
    • 财政年份:
      2006
    • 负责人:
      KATSURA Masashi
    • 依托单位:
    Identification of common process underlying establishment of drug dependence and an attempt to develop pharmacogenomic therapy.
    • 批准号:
      16590212
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2004
    • 负责人:
      KATSURA Masashi
    • 依托单位:
    Functional alteration in high voltage-gated calcium channels in drug dependence and elucidation of its mechanisms.
    • 批准号:
      14570095
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2002
    • 负责人:
      KATSURA Masashi
    • 依托单位:
    海外基金