Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse
Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse
批准号:
20590294
负责人:
MAEKAWA Toshio
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
By the analyses of knockout mice of the ATF-2 gene family members, I have analyzed the physiological functions of ATF-2 gene family members. I have found that ATF-2 contribute to the developments of central nervous systems and macrophages. ATF-2 and CRE-BPa also contribute to the differentiations to the adipose tissue. On the other hand, ATF-7 represses the transcription of serotonin receptor 5b in the dorsal raphe nucleus in the brain stem. By the depletion of ATF-7, serotonin concentration was reduced and mouse showed abnormal behaviors.
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Stress-induced epigenetic regulation via ATF-2 family transcription factors
通过 ATF-2 家族转录因子进行应激诱导的表观遗传调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[S.Ishii, K.Seong, H.Shimizu, D.Li, T.Maekawa]
通讯作者:
T.Maekawa
Socail isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
社会隔离应激会诱导 ATF-7 磷酸化并损害 5-HT 5B 受体基因的沉默。
DOI:
--
发表时间:
2010
期刊:
EMBO J. 29
影响因子:
--
作者:
[Maekawa T, Kim S-J, Nakai D, Makino C, Takagi T, Orura H, Yamada K, Chatton B, Ishii S]
通讯作者:
Ishii S
DOI:
10.1016/j.bbrc.2009.05.001
发表时间:
2009-07
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[N. Hirose;T. Maekawa;T. Shinagawa;S. Ishii]
通讯作者:
N. Hirose;T. Maekawa;T. Shinagawa;S. Ishii
Role of ATF-2 family of transcription factorsin adipocyte differentiation : anti-obesity effect of p38 inhibitor
ATF-2 转录因子家族在脂肪细胞分化中的作用:p38 抑制剂的抗肥胖作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[T.Maekawa, S.Ishii]
通讯作者:
S.Ishii
ATF-7依存的なヒストンH3メチル化を介したストレスによる転写制御
通过 ATF-7 依赖性组蛋白 H3 甲基化进行应激诱导的转录调控
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[前川利男, 中井大助, 金昇準, 吉田圭介, 小倉博雄, 山田一之, 石井俊輔]
通讯作者:
石井俊輔
共 13 条
Transgenerational inheritance of altered gene expression via stress
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批准号:23659165
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:MAEKAWA Toshio
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依托单位:
Functional analysis of ATF-2 gene family members by using gene knockout mouse
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批准号:14570114
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:MAEKAWA Toshio
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依托单位:
Functional analyses of ATF-2 gene family members by using knockout-mouse
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批准号:12670126
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:2000
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负责人:MAEKAWA Toshio
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依托单位:
Analysis of transcrition regulators involved in intracellular signaling
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批准号:08670159
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:MAEKAWA Toshio
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依托单位:
Analysis of transcriptional regulator involved in signal transduction in lymphocyte
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批准号:05670313
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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负责人:MAEKAWA Toshio
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依托单位:
Analysis of transcriptional regulator in lymphocyte
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批准号:03670257
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1991
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负责人:MAEKAWA Toshio
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依托单位:
国内基金
低钾营养状态下基于p38–ATF-7信号通路调控衰老的机制
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批准号:--
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项目类别:面上项目
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资助金额:55万元
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批准年份:2021
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负责人:吴紫云
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依托单位: