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Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse

Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse
利用敲除小鼠进行ATF-2基因家族成员转录因子的功能分析
批准号:
20590294
负责人:
MAEKAWA Toshio
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
By the analyses of knockout mice of the ATF-2 gene family members, I have analyzed the physiological functions of ATF-2 gene family members. I have found that ATF-2 contribute to the developments of central nervous systems and macrophages. ATF-2 and CRE-BPa also contribute to the differentiations to the adipose tissue. On the other hand, ATF-7 represses the transcription of serotonin receptor 5b in the dorsal raphe nucleus in the brain stem. By the depletion of ATF-7, serotonin concentration was reduced and mouse showed abnormal behaviors.
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会议论文
Stress-induced epigenetic regulation via ATF-2 family transcription factors
通过 ATF-2 家族转录因子进行应激诱导的表观遗传调控
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [S.Ishii, K.Seong, H.Shimizu, D.Li, T.Maekawa]
通讯作者: T.Maekawa
Socail isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
社会隔离应激会诱导 ATF-7 磷酸化并损害 5-HT 5B 受体基因的沉默。
DOI: --
发表时间: 2010
期刊: EMBO J. 29
影响因子: --
作者: [Maekawa T, Kim S-J, Nakai D, Makino C, Takagi T, Orura H, Yamada K, Chatton B, Ishii S]
通讯作者: Ishii S
DOI: 10.1016/j.bbrc.2009.05.001
发表时间: 2009-07
期刊: Biochemical and biophysical research communications
影响因子: 3.1
作者: [N. Hirose;T. Maekawa;T. Shinagawa;S. Ishii]
通讯作者: N. Hirose;T. Maekawa;T. Shinagawa;S. Ishii
Role of ATF-2 family of transcription factorsin adipocyte differentiation : anti-obesity effect of p38 inhibitor
ATF-2 转录因子家族在脂肪细胞分化中的作用:p38 抑制剂的抗肥胖作用
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [T.Maekawa, S.Ishii]
通讯作者: S.Ishii
13
    Transgenerational inheritance of altered gene expression via stress
    Functional analysis of ATF-2 gene family members by using gene knockout mouse
    Functional analyses of ATF-2 gene family members by using knockout-mouse
    Analysis of transcrition regulators involved in intracellular signaling
    国内基金
    低钾营养状态下基于p38–ATF-7信号通路调控衰老的机制
    • 批准号:
      --
    • 项目类别:
      面上项目
    • 资助金额:
      55万元
    • 批准年份:
      2021
    • 负责人:
      吴紫云
    • 依托单位: