Transgenerational inheritance of altered gene expression via stress

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A paternal “low-protein” diet altered gene expressions, mainly involved in lipid and cholesterol biosynthesis, in the livers of offspring even though the maternal diet was unaltered (Carone BR, Cell, 2010). We have studied the effect of ATF-7 on these gene expressions and have found that using Atf-7 knockout male mice low-protein diet didn’t alter expressions of cholesterol biosynthesis genes. And we have found that ATF-7 binds to the promoter regions of about half of these cholesterol biosynthesis genes. And also, in the promoter regions of these genes, the degrees of histone H3K9 methylation were reduced.