Investigation of epigenetic abnormalities involved in lung cancer progression.

肺癌进展中涉及的表观遗传异常的研究。

• 批准号: 20590324
• 负责人: OSADA Hirotaka
• 金额: $ 2.91万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590324/
• 关键词: 分子腫瘍学; 癌; 肺癌; エピジェネティック; マイクロRNA; 転移; ASH1

Lung cancers with neuroendocrine features are usually highly metastatic and aggressive. We investigated the relationship between ASH1 signaling and epigenetic abnormalities in lung cancers, because neuroendocrine features are induced by ASH1. Our findings revealed a novel tumor suppressor candidate gene, which is suppressed by ASH1 signaling and epigenetic abnormalities. We also found ASH1-upregulated miRNA and characterized the epigenetic status of its promoter region. Finally, a tetracycline-inducible ASH1 expression system was established.

具有神经内分泌特征的肺癌通常具有高度转移性和侵袭性。我们研究了ASH1信号传导和肺癌表观遗传异常之间的关系，因为神经内分泌特征是由ASH1诱导的。我们的研究结果揭示了一个新的肿瘤抑制候选基因，这是抑制ASH1信号和表观遗传异常。我们还发现了ASH1上调的miRNA，并表征了其启动子区域的表观遗传状态。最后，建立了四环素诱导的ASH1表达系统。

项目成果

Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer

• DOI: 10.1158/0008-5472.can-07-5039
• 发表时间: 2008-03-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Osada, Hirotaka;Tomida, Shuta;Takahashi, Takashi
• 通讯作者: Takahashi, Takashi

Novel Metastasis-Related Gene CIM Functions in the Regulation of Multiple Cellular Stress-Response Pathways

• DOI: 10.1158/0008-5472.can-10-1055
• 发表时间: 2010-12-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Yanagisawa, Kiyoshi;Konishi, Hiroyuki;Takahashi, Takashi
• 通讯作者: Takahashi, Takashi

Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers

• DOI: 10.1002/ijc.25225
• 发表时间: 2010-11-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: An, Byonggu;Kondo, Yutaka;Sekido, Yoshitaka
• 通讯作者: Sekido, Yoshitaka

ADw1, a novel gene, is frequently inactivated in lung cancer and involved in cell-cell contact

ADw1 是一种新基因，在肺癌中经常失活并参与细胞间接触

• 发表时间: 2008
• 作者: Hamano R.;Ishii H.;et.al;Osada H
• 通讯作者: Osada H

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells

• DOI: 10.1093/carcin/bgp097
• 发表时间: 2009-07-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Kawaguchi, Koji;Murakami, Hideki;Sekido, Yoshitaka
• 通讯作者: Sekido, Yoshitaka