Cell lineage-related mechanisms involved in lung cancer stem cell development.

肺癌干细胞发育中涉及的细胞谱系相关机制。

• 批准号: 23501281
• 负责人: OSADA Hirotaka
• 金额: $ 3.08万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23501281/
• 关键词: 肺がん; 幹細胞; がん幹細胞; 癌幹細胞

Sphere-forming cells were initially established from several different lung cancer cell lines, after which expression profiling and tumorigenesis assay findings indicated their cancer stem cell properties. In addition, expression of neuroendocrine-related genes in these cells suggests a possible association between sphere formation and cell lineage plasticity. Furthermore, neuroendocrine-inducing ASH1 has also been found to promote sphere formation in some cell lines, suggesting the involvement of ASH1 signaling in development of cancer stem cells.

球体形成细胞最初是从几种不同的肺癌细胞系中建立的，之后，表达谱和肿瘤发生实验结果表明了它们的癌症干细胞特性。此外，这些细胞中神经内分泌相关基因的表达表明球体形成与细胞谱系可塑性之间可能存在关联。此外，神经内分泌诱导的ASH1也被发现在一些细胞系中促进球的形成，这表明ASH1信号通路参与了癌症干细胞的发育。

项目成果

The circadian clock gene BMAL1 is a novel therapeutic target for malignant mesothelioma

生物钟基因BMAL1是恶性间皮瘤的新治疗靶点

• 发表时间: 2012
• 期刊: Int J Cancer
• 影响因子: 6.4
• 作者: Elshazley M;Sato M;Hase T;Takeyama Y;Yamashita R;Yoshida K;Toyokuni S;Ishiguro F;Osada H;Sekido Y;Yokoi K;Usami N;Shames DS;Kondo M;Gazdar AF;Minna JD;Hasegawa Y
• 通讯作者: Hasegawa Y

miR-375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancermiR-375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer

在肺癌中，miR-375 被 ASH1 激活，并以谱系依赖性方式抑制 YAP1 在肺癌中，miR-375 被 ASH1 激活，并以谱系依赖性方式抑制 YAP1

• 发表时间: 2011
• 期刊: Cancer Res
• 影响因子: 11.2
• 作者: Nishikawa E;Osada H;Okazaki Y;Arima C;Tomida S;Tatematsu Y;Taguchi A;Shimada Y;Yanagisawa K;Yatabe Y;Toyokuni S;Sekido Y;Takahashi T
• 通讯作者: Takahashi T

Epithelial to mesenchymal transition in an EGFR-mutant lung cancer cell line with acquired resistance to erlotinib

对厄洛替尼获得性耐药的 EGFR 突变肺癌细胞系的上皮细胞向间质细胞转变

• 发表时间: 2011
• 期刊: J Thorac Oncol
• 影响因子: 20.4
• 作者: Suda K;Tomizawa K;Fujii M;Murakami H;Osada H;Maehara Y;Yatabe Y;Sekido Y;Mitsudomi T
• 通讯作者: Mitsudomi T

Overexpression of activated leukocyte cell adhesion molecule is involved in invasion of malignant mesothelioma cells

活化白细胞粘附分子过度表达参与恶性间皮瘤细胞侵袭

• 发表时间: 2011
• 作者: 野村 幸世;愛甲 丞;大本 安一;多田 稔;大津 洋;三浦 洋菜;山形 幸徳;瀬戸 泰之;上西 紀夫;Mizuno T;野村 幸世;Ishiguro F
• 通讯作者: Ishiguro F

YAP transcription coactivator induces malignant mesothelioma cell proliferation by up-regulating cell cycle progression

YAP转录共激活剂通过上调细胞周期进程诱导恶性间皮瘤细胞增殖

• 发表时间: 2011
• 作者: Osada H;Takahashi T;野村 幸世;Osada H;Mizuno T
• 通讯作者: Mizuno T