Cell lineage-related mechanisms involved in lung cancer stem cell development.

最初从几种不同的肺癌细胞系中建立了球体形成细胞，之后表达谱和肿瘤发生测定结果表明它们具有癌症干细胞特性。此外，这些细胞中神经内分泌相关基因的表达表明球体形成和细胞谱系可塑性之间可能存在关联。此外，神经内分泌诱导的ASH1也被发现在一些细胞系中促进球体形成，这表明ASH1信号转导参与了癌症干细胞的发育。

Sphere-forming cells were initially established from several different lung cancer cell lines, after which expression profiling and tumorigenesis assay findings indicated their cancer stem cell properties. In addition, expression of neuroendocrine-related genes in these cells suggests a possible association between sphere formation and cell lineage plasticity. Furthermore, neuroendocrine-inducing ASH1 has also been found to promote sphere formation in some cell lines, suggesting the involvement of ASH1 signaling in development of cancer stem cells.