Analyses of a vesicular transport protein taxilin in tumorigenesis

一种假定的囊泡转运蛋白，taxilin，在分泌细胞如正常结肠和直肠的神经内分泌细胞中表达。另一方面，它在结肠癌、前列腺癌、乳腺癌以及胶质母细胞瘤、骨肉瘤和黑色素瘤细胞中的表达似乎有所增加。在转移性乳腺癌细胞系中抑制taxilin可诱导细胞生长和侵袭性降低，并上调对抗癌药物的敏感性，提示其在特定类型癌症中的功能作用。

A putative vesicular transport protein, taxilin, is expressed in secreting cells such as neuroendocrine cells in the normal colon and rectum. On the other hand, its expression appeared to be elevated in the colon cancer, prostate cancer, and breast cancer as well as in glioblastoma, osteosarcoma, and melanoma cells. The suppression of taxilin in the metastatic breast cancer cell line induced the reduction of cell growth and invasiveness and upregulted the susceptibility to anti-cancer drug, suggesting its functional implication in the specific type of cancer.