Novel role of ALOX5 (L22) in the control of antibody production

我们以前报道过L22单抗，它可以很好地定义人原代静息B细胞和淋巴样卵泡的其他免疫细胞。在这项研究中，我们首先将l22 Ag鉴定为花生四烯酸5-脂氧合酶（Alox5），我们的实验结果说明了Alox5在体内通过管理幼稚和记忆B细胞以及滤泡辅助性T细胞产生特异性抗体过程中的新作用。由于Alox5是提供白三烯等脂质介质的关键酶，因此进一步关注代谢组学的研究可能为先天性和适应性免疫反应的机制以及过敏性和慢性炎症疾病的发病机制提供新的见解（Nagashima T, et al.）。美国病理学杂志，2011)。

We have previously reported L22 mAb with which human primary resting B cells and other immune cells of lymphoid follicles are well defined. In this study, we first identifiedL22 Ag as arachidonate 5-lipoxyganase (Alox5) and our experimental results illustrated the novel role of Alox5 during the process of specific antibody production by managing naive and memory B cells as well as follicular helper T cells in vivo. Because Alox5 is a key enzyme giving lipid mediators like leukotrienes, further investigations focusing on metabolome may provide new insights into the mechanisms of innate and adaptive immune responses and the pathogenesis of allergic and chronic inflammatory disorders (Nagashima T, et al. American Journal of Pathology, 2011).