Analysis of antibody production program underlying immune-related disorders of human system

滤泡辅助性T细胞（Follicular Helper T，Tfh）在高亲和力抗体的产生中起着重要作用，其可塑性使其成为其他效应辅助性T细胞，然而，人Tfh细胞的调节机制尚未完全阐明。在这项研究中，我们的目的是了解人类Tfh细胞的生物医学特性。结果表明，阻塞性睡眠呼吸暂停综合征患者的肥大扁桃体中，Tfh细胞优先存在于增大的淋巴滤泡内。当检查包括过敏性鼻炎或哮喘在内的免疫相关疾病患者的血液Tfh细胞时，主要观察到Tfh 2细胞。到目前为止，Tfh细胞分化的不寻常方式（在本研究中称为Tfh-转变或Tfh 2-转变）将归因于此类病症的基础病症。尽管ALOX 5相关的脂质介质和/或POU 2AF 1可能参与人Tfh细胞的偏斜分化，但仍需要进一步的研究。

Follicular helper T (Tfh) cells play a cardinal role in the production of high-affinity antibodies and their plasticity enables to become other effector helper T cells; however, regulatory mechanism of human Tfh cells is not fully elucidated. In this study we aimed to understand biomedical features of human Tfh cells. Results demonstrated that hypertrophic tonsils of the patients with obstructive sleep apnea syndrome preferentially possessed Tfh cells within enlarged lymphoid follicles. When examined blood Tfh cells of patients with immune-related disorders including allergic rhinitis or asthma, Tfh2 cells were predominantly observed. Thus far unusual manner of Tfh cell differentiation (named Tfh-shift or Tfh2-shift in this study) would be attributable for underlying conditions of such disorders. Further studies should be required, although ALOX5-related lipid mediators and/or POU2AF1 might be involved in the skewed differentiation of human Tfh cells.