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Impact of the aPKC/PAR system on carcinogenesis and progression.

Impact of the aPKC/PAR system on carcinogenesis and progression.
aPKC/PAR 系统对癌发生和进展的影响。
批准号:
20590368
负责人:
NAGASHIMA Yoji
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
aPKCλ/ιhas a pivotal role in establishment and maintenance of cell polarity. In this study, we demonstrated that (1) aPKCλ/ιis overexpressed in various cancer cells, including breast and prostate cancers, (2) aPKCλ/ιinduces IL6 expression to obtain castration resistance in prostatic cancer (aPKC-IL6 pathway), and (3) correlation of expression of aPKCλ/ι and IL6 was demonstrated in the breast cancer as well as prostatic cancer.
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aPKC and IL-6 expression in prostate cancer tissues.
前列腺癌组织中aPKC和IL-6的表达。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano J, Takagawa R, Sasaki K, Fujinami K, Aoki I, Ohno S, Kubota Y, Uemura H]
通讯作者: Uemura H
DOI: 10.3892/etm_00000073
发表时间: 2010-05-01
期刊: EXPERIMENTAL AND THERAPEUTIC MEDICINE
影响因子: 2.7
作者: [Kang, Yun, Omura, Motoko, Inoue, Tomio]
通讯作者: Inoue, Tomio
Mutations of c-kit gene in bilateral testicular germ cell tumours in Japan
日本双侧睾丸生殖细胞肿瘤c-kit基因突变
DOI: --
发表时间: 2008
期刊: Cancer Lett 259(2)
影响因子: --
作者: [Sakuma, Y, et. al.]
通讯作者: et. al.
Gene expression during liver regeneration after partial hepatectomy in mice lacking type 1 tumor necrosis factor receptor.
缺乏1型肿瘤坏死因子受体的小鼠部分肝切除术后肝再生过程中的基因表达。
DOI: --
发表时间: 2009
期刊: Journal of Surgical Research
影响因子: 2.2
作者: [Tetsuya Shimizu, S. Togo, Takahumi Kumamoto, H. Makino, Tomoyuki Morita, Kuniya Tanaka, T. Kubota, Y. Ichikawa, Y. Nagasima, Y. Okazaki, Y. Hayashizaki, H. Shimada]
通讯作者: H. Shimada
108
    Role of aPKC-IL6 pathway, especially in prostatic and berast cancers
    • 批准号:
      26460456
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2014
    • 负责人:
      NAGASHIMA Yoji
    • 依托单位:
    Role and possibility as a therapeutic target of aPKClambda/iota in intractable cancers
    • 批准号:
      23590429
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2011
    • 负责人:
      NAGASHIMA Yoji
    • 依托单位:
    Establishment of an experimental therapy for aggressive renal cell carcinoma by knock-down of SPARC gene expression.
    • 批准号:
      18590376
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.53万
    • 财政年份:
      2006
    • 负责人:
      NAGASHIMA Yoji
    • 依托单位:
    MOLECULAR BIOLOGICAL RESEARCH ON THE PRECURSOR AND PRECANCEROUS LESIONS OF THE KIDNEY-ANALYSIS WITH LASER CAPTURE MICRODISSECTION AND CHROMOGENIC IN SITU HYBRIDIZATION-
    • 批准号:
      15590309
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2003
    • 负责人:
      NAGASHIMA Yoji
    • 依托单位:
    海外基金