Relation between cell morphology and higher-order or angstrom level alteration of chromosomes and DNA architecture

在这项研究中，我们提出了这些异常染色体区域（CT）的CS10，CS 18，甲状腺癌细胞核DNA和CS 19的变化;膀胱尿路上皮癌细胞核DNA与染色体/基因数目的关系;宫颈鳞状上皮化生细胞1号染色体上表皮分化复合物（EDC）基因亚染色体定位的变化;宫颈鳞状上皮化生1号染色体上EDC基因周围DNA的浓缩程度较低，提示染色体和DNA结构的高阶或埃级改变可能通过RNA转录活性的改变与细胞形态有关。

In this study, we present thati) abnormal chromosome territories (CTs) of the CS10, CS18, and CS19 in thyroid carcinomas.ii) relation between of nuclear atypia and number of chromosomes/genes in urothelial carcinomas of the urinary bladder.iii) change of subchromosomal positioning (SCP) of epidermal differentiation complex (EDC) gene in CT of chromosome 1 in squamous cell metaplasia of the uterine cervix.iv) less condensation of DNA around EDC gene in chromosome 1 of squamous cell metaplasia of the uterine cervix.From the above results, we concluded that higher-order or angstrom level alteration of chromosomes and DNA architecture could be related to cell morphology through RNA transcription activity change.