Development of early diagnosis of malignant mesothelioma : Comprehensive analysis of secretory and membrane proteins

恶性间皮瘤早期诊断的进展：分泌蛋白和膜蛋白的综合分析

• 批准号: 20590377
• 负责人: TSUJIMURA Tohru
• 金额: $ 3.08万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590377/
• 关键词: 分子病理; 中皮腫; 診断マーカー

We made monoclonal antibodies by using a malignant mesothelioma cell line as an immunogen, and obtained a clone of monoclonal antibody which reacts with a surface molecule of malignant mesothelioma, but not that of pulmonary adenocarcinoma. This clone showed strong immunoreactivity for malignant mesothelioma. In addition, we identified a cell adhesion molecule, which was expressed in malignant mesothelioma cells, but not reactive mesothelial cells, in pleural effusion. The clone of monoclonal antibody and the cell adhesion molecule may be useful for early diagnosis of malignant mesothelioma.

我们用恶性间皮瘤细胞系作为免疫原制备了单克隆抗体，并获得了与恶性间皮瘤表面分子反应而不与肺腺癌表面分子反应的单克隆抗体克隆。该克隆表现出恶性间皮瘤的强免疫反应性。此外，我们确定了细胞粘附分子，这是恶性间皮瘤细胞，但不反应性间皮瘤细胞，胸腔积液中表达。本研究克隆的单克隆抗体和细胞粘附分子可能有助于恶性间皮瘤的早期诊断。

项目成果

Well-differentiated papillary mesothelioma with invasion to the chest wall.

分化良好的乳头状间皮瘤，侵犯胸壁。

• 发表时间: 2010
• 期刊: Lung Cancer. 67
• 作者: Torii I;Sato A;Tsujimura T;et al
• 通讯作者: et al

Circulating tumor cells (CTCs) and endothelial cells (CECs) in the diagnosis of malignant pleural mesothelioma (MPM) : a single institutional prospective stud

循环肿瘤细胞（CTC）和内皮细胞（CEC）在恶性胸膜间皮瘤（MPM）诊断中的应用：一项机构前瞻性研究

• 发表时间: 2009
• 作者: Yoneda K;Tsujimura T;Nakano T et al
• 通讯作者: Nakano T et al

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

• DOI: 10.1038/ni.1622
• 发表时间: 2008-07-01
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Uematsu, Satoshi;Fujimoto, Kosuke;Akira, Shizuo
• 通讯作者: Akira, Shizuo

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.

• DOI: 10.1038/ni.1885
• 发表时间: 2010-07
• 期刊: Nature immunology
• 影响因子: 30.5

Diagnosis of malignant pleural mesothelioma in effusion cytology -Discrimination between mesothelioma and reactive mesothelium-

恶性胸膜间皮瘤的积液细胞学诊断-间皮瘤与反应性间皮瘤的鉴别-

• 发表时间: 2010
• 作者: Okabe M;Tsujimura T;Miyajima A;et al;辻村亨;Tsujimura T
• 通讯作者: Tsujimura T