Analysis of basic mechanisms of osteoclastogenesis to apply to clinical study

破骨细胞生成基本机制分析及其应用于临床研究

• 批准号: 20590400
• 负责人: HAYASHI Shin-ichi
• 金额: $ 3.08万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590400/
• 关键词: 炎症; 破骨細胞; 免疫学; 骨吸収; 発生・分化; 病理学; 再生医学

Bones are resorbed both in the steady and pathological states ; however, it is not clear whether the regulation of osteoclastogenesis is same. Here, I detected the presence of the regulation of bone resorption from extramedullary sites. Intramedullary T lineage cells but also the cells in the peritoneal cavity might control the osteoclastogenesis. These results suggest that the novel therapy for bone diseases such as osteoporosis or arthritis will be opened.

骨在稳定状态和病理状态下均被吸收，但破骨细胞生成的调节是否相同尚不清楚。在这里，我检测到存在的调节骨吸收髓外网站。髓内T细胞和腹腔内T细胞可能共同控制破骨细胞的生成。这些结果表明，骨质疏松症或关节炎等骨疾病的新疗法将被打开。

项目成果

Analysis of capturing skin antigens in the steady state using milk fat globule EGF factor 8-deficient skin-hyperpigmented mice.

使用乳脂肪球 EGF 因子 8 缺陷的皮肤色素沉着过度小鼠在稳态下捕获皮肤抗原的分析。

• 发表时间: 2008
• 期刊: Immunology Letters 115(2)
• 作者: Yoshino M;et. al.
• 通讯作者: et. al.

Delta-like 1 functions as an adhesion molecule for mast cells

Delta-like 1 作为肥大细胞的粘附分子

• 发表时间: 2010
• 期刊: J.Immunol.
• 作者: Murata;A.;et al.
• 通讯作者: et al.

A Notch Ligand, Delta-Like 1 Functions As an Adhesion Molecule for Mast Cells

• DOI: 10.4049/jimmunol.1000195
• 发表时间: 2010-10-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Murata, Akihiko;Okuyama, Kazuki;Hayashi, Shin-Ichi
• 通讯作者: Hayashi, Shin-Ichi

CCR7-independent trafficking of skin antigens to regional lymphnodes by cells in the dermis

真皮细胞将皮肤抗原不依赖于 CCR7 运输至区域淋巴结

• 发表时间: 2010
• 作者: Yoshino;M.;et al.
• 通讯作者: et al.

B220^+ Cd19^+ Flt3^+ Il7rα^+ bone-marrow precursors give rise to B-lineage cells in the presence of a Notch ligand, Delta-like 1 (1-E-W7-6-0/P).

B220^+ Cd19^+ Flt3^+ Il7rα^+ 骨髓前体在 Notch 配体 Delta 样 1 (1-E-W7-6-0/P) 存在下产生 B 谱系细胞。

• 发表时间: 2009
• 作者: Okuyama;K.;et al.
• 通讯作者: et al.