Analysis of basic mechanisms of osteoclastogenesis to apply to clinical study

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Bones are resorbed both in the steady and pathological states ; however, it is not clear whether the regulation of osteoclastogenesis is same. Here, I detected the presence of the regulation of bone resorption from extramedullary sites. Intramedullary T lineage cells but also the cells in the peritoneal cavity might control the osteoclastogenesis. These results suggest that the novel therapy for bone diseases such as osteoporosis or arthritis will be opened.