Modeling and inter-individual difference of pharmacokinetics of persistent organofluorine compounds

点击翻译按钮获取中文摘要

Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical. PFOA shows extremely long half-life in humans. Long chain homologues in serum were increased in a decade. We developed toxicokinetics model and modeling of serum levels in general population agreed with observed levels. We found a large renal excretion of PFOA in Abcb4-deficient mice and using a microarray approach ATP-binding cassette, sub-family B, member 1B (Abcb1b) was shown to be a renal transporter of PFOA using abcb1a/1b null mice.