Searching genes susceptible for life-style related diseases, such as diabetes and hypertension.

寻找易患生活方式相关疾病的基因，例如糖尿病和高血压。

• 批准号: 20590595
• 负责人: DAIMON Makoto
• 金额: $ 3.08万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590595/
• 关键词: 分子遺伝疫学; 高畠研究; 住民研究; 遺伝子多型; 2型糖尿病; GNB3遺伝子; 高血圧; Clu遺伝子; インスリン抵抗性; 分子疫学; 生活習慣病; 糖尿病; 肥満; FTO遺伝子; 運動量; エネルギー摂取量; hOGG1; DNA修復酵素; GNB3; 塩分摂取量

Most studies to find genes susceptible for life-style related diseases have been conducted without regard for life-style per se. This strategy conveys a risk that the results obtained were not useful in ordinary clinical settings. Therefore, we search genes susceptible for life-style related diseases with detailed information of life-styles such as nutritional intakes and physical activities, and found several genes susceptible for life-style related diseases. Of them, tow genes (GNB3 and FTO) were found as associated with diabetes in relation with salt intake and obesity in relation with physical activities, respectively. These findings seem to be very useful in ordinary clinical settings.

大多数寻找生活方式相关疾病易感基因的研究都没有考虑生活方式本身。该策略存在获得的结果在普通临床环境中没有用的风险。因此，我们通过详细的生活方式信息，如营养摄入和身体活动，寻找生活方式相关疾病的易感基因，并发现了几个生活方式相关疾病的易感基因。其中，发现两个基因（GNB3和FTO）分别与糖尿病（与盐摄入量有关）和肥胖（与体力活动有关）相关。这些发现似乎在普通临床环境中非常有用。

项目成果

Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM

• DOI: 10.1016/j.bbrc.2008.07.065
• 发表时间: 2008-09-26
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Daimon, Makoto;Sato, Hidenori;Kato, Takeo
• 通讯作者: Kato, Takeo

Salt consumption-dependent association of the GNB3 gene poly-morphism with type 2 diabetes

GNB3 基因多态性与 2 型糖尿病的盐消耗依赖性关联

• 发表时间: 2008
• 期刊: Biochemical and Biophysical Research Communications 374
• 作者: Inoue A;Kobayashi K;Usui K;Maemondo M;Okinaga S;Mikami I;Ando M;Yamazaki K;Saijo Y;Gemma A;Miyazawa H;Tanaka T;Ikebuchi K;Nukiwa T;Morita S;Hagiwara K ; North East Japan Gefitinib Study Group;Makoto Daimon
• 通讯作者: Makoto Daimon

5年後の糖尿病発症リスクを指標とした耐糖能の評価基準の検討

以5年内患糖尿病的风险为指标的糖耐量评价标准的探讨

• 发表时间: 2011
• 作者: 大門真;他
• 通讯作者: 他

Higher plasma renin activity is a risk factor for total mortality in older Japanese individuals: the Takahata study

• DOI: 10.1016/j.metabol.2011.08.004
• 发表时间: 2012-04-01
• 期刊: METABOLISM-CLINICAL AND EXPERIMENTAL
• 影响因子: 9.8
• 作者: Daimon, Makoto;Konta, Tsuneo;Kato, Takeo
• 通讯作者: Kato, Takeo

Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations

LIPC基因的内含子单倍型与两个独立群体中高α脂蛋白血症的关联

• DOI: 10.1007/s10038-007-0236-0
• 发表时间: 2008
• 期刊: J HumGenet
• 作者: Iijima H;Emi M;Wada M;et al.
• 通讯作者: et al.