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Neurobehavioral changes in metallothionein-null mice postnatal exposed to low levels mercury vapor.

出生后暴露于低水平汞蒸气的金属硫蛋白缺失小鼠的神经行为变化。

基本信息

批准号：
20590611
负责人：
YOSHIDA Minoru
金额：
$ 3.08万
依托单位：
Hachinohe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

Metallothionein MT-null and wild-type mice were repeatedly exposed to Hg^0 at 0.057 mg/m^3, which were similar to the current threshold value (TLV), until the 20th of postpartum. Hg^0-exposed mice of both strains did not show behavioral changes such as total locomotor activity, learning ability and spatial learning ability. However, Hg^0 exposure resulted in significant alterations in gene expression in the brain of both strains using DNA microarray analysis. A number of altered genes in MT-null mice were more than those in wild-type mice. When the exposure levels elevated to 0.198mg/m^3, MT-null mice showed a significant decrease in total locomotor activity in female, though learning ability and spatial learning ability were not affected. A number of altered genes were further increased by elevation of Hg^0 exposure levels. DNA microarray analysis may provide useful information to elucidate development of behavioral toxicity following a low-level exposure to Hg^0.

金属硫蛋白MT缺失和野生型小鼠重复暴露于0.057 mg/m^3的Hg^0，其与当前阈值（TLV）相似，直到产后20日。两种品系的 Hg^0 暴露小鼠均未表现出行为变化，如总运动活动、学习能力和空间学习能力。然而，通过 DNA 微阵列分析，Hg^0 暴露导致两种菌株大脑中基因表达的显着改变。 MT缺失小鼠中的一些改变基因数量比野生型小鼠更多。当暴露水平升高至0.198mg/m^3时，MT缺失小鼠的雌性总运动活动显着下降，但学习能力和空间学习能力未受影响。 Hg^0 暴露水平的升高进一步增加了许多改变的基因。 DNA 微阵列分析可以提供有用的信息来阐明低水平接触 Hg^0 后行为毒性的发展。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Emergence of delayed methylmercury toxicity after perinatal exposure in metallothionein-null and wild-type C57BL mice.

DOI：
10.1289/ehp.10906
发表时间：
2008-06
期刊：
ENVIRONMENTAL HEALTH PERSPECTIVES
影响因子：
10.4
作者：
Yoshida, Minoru;Shimizu, Natsuki;Suzuki, Megumi;Watanabe, Chiho;Satoh, Masahiko;Mori, Kouki;Yasutake, Akira
通讯作者：
Yasutake, Akira

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