A case-control study of breast cancer in relation to the risk for estrogen levels in breast tissue and in situ estrogen production
A case-control study of breast cancer in relation to the risk for estrogen levels in breast tissue and in situ estrogen production
批准号:
20590630
负责人:
MINAMI Yuko
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
We investigated the associations between hormone levels in blood and in breast cancer tissue and risk factors of breast cancer using data from 62 postmenopausal breast cancer patients. Estradiol (E2) level in tissue was 43.7 times compared with that in blood among patients with ER+ or PR+ breast cancer, whereas 14.5 times among patients with ER-/PR-. In addition, E2 level in receptor positive breast cancer tissue tended to be higher among breast cancer patients with history of breast feeding. There is a possibility that E2 is produced in breast tissue or taken from blood. History of breast feeding may be related to the mechanisms responsible for the accumulation of E2 in breast tissue.
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Effects of reproductive factors and exogenous hormone use on the risk of gynecologic cancers : a case-control study
生殖因素和外源激素使用对妇科癌症风险的影响:病例对照研究
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[河合賢朗, 南優子, Nishino Y]
通讯作者:
Nishino Y
Case-control study of green tea consumption and the risk of endometrial endometroid adenocarcinoma
绿茶摄入量与子宫内膜样腺癌风险的病例对照研究
DOI:
--
发表时间:
2009
期刊:
Cancer Causes Control 20巻
影响因子:
--
作者:
[Kakuta Y]
通讯作者:
Kakuta Y
日本人女性における成人期の肥満、体重変化と乳がんリスクの関連
日本成年女性肥胖、体重变化与乳腺癌风险之间的关联
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[河合賢朗, 南優子]
通讯作者:
南優子
17b-hydroxysteroid dehydrogenase type 12 in human breast carcinoma : a prognostic factor via potential regulation of fatty acids synthesis
人乳腺癌中的 17b-羟基类固醇脱氢酶 12 型:通过潜在调节脂肪酸合成的预后因素
DOI:
--
发表时间:
2009
期刊:
Cancer Res 69
影响因子:
--
作者:
[Nagasaki S, Suzuki T, Miki Y, Akahira J, Kitada K, Ishida T, Handa H, Ohuchi N, Sasano H]
通讯作者:
Sasano H
共 13 条
Contribution of new cancer related gene OCIAD2 to carcinogenesis and malignant alteration of pulmonary adenocarcinoma
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批准号:20590362
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2008
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负责人:MINAMI Yuko
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依托单位:
A cohort study of systemic lupus erythematosus for elucidating the association between intake of isoflavones and prognosis
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批准号:18590588
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2006
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负责人:MINAMI Yuko
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依托单位:
海外基金