Contribution of new cancer related gene OCIAD2 to carcinogenesis and malignant alteration of pulmonary adenocarcinoma

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Polyclonal antibody against the recombinant peptides of OCIAD domain containing 2 (OCIAD2) that was highly expressed in early invasive pulmonary adenocarcinoma was produced and we examined the expression of OCIAD2 in 133 small-sized lung adenocarcinomas and 118 mucinous ovarian carcinomas. There was no correlation between OCIAD2 expression and outcomes for lung adenocarcinoma. However, although almost all normal lung tissue was negative for OCIAD2, a number of tumour cells were stained by OCIAD2 antibody, therefore,OCIAD2 was thought to be lung adenocarcinoma specific cancer related antigen. On the other hand, OCIAD2 expression significantly correlated with malignant alteration in ovarian mucinous tumour. Histologicaly, OCIAD2 was strongly expressed in the papillary formation or the stromal invasion of tumour cells. It was expected that OCIAD2 might be secreted in the ascites or the serum of the patients with mucihous ovarian cancer. In order to construct the detection system for OCIAD2 in the ascites or the serum, we transplanted OCIAD2 positive ovarian tumour cell to the nude-mice, then made the genograft mice. The genograft tumour also revealed the OCIAD2 expression.