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Development of a chronic stress-induced low-grade fever animal model and its mechanisms

慢性应激低热动物模型的建立及其机制

基本信息

批准号：
20590711
负责人：
OKA Takakazu
金额：
$ 3.08万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

项目摘要

To obtain a better understanding of patients with persistent low-grade fever that develops in psychosocially stressful situations, we aimed to develop a stress-induced chronic low-grade fever (hyperthermia) animal model. We measured core body temperature (Tc) in male Wistar rats after they were subjected to 4 social defeat periods (each period consisting of 7 daily 1 h stress exposures during the light cycle followed by a stress-free day). After 4 periods of social defeat, stressed rats showed a small but significantly higher (+0.2-0.3℃) Tc versus control rats during both light and dark periods. They also showed depression-like behavior. Hyperthermia and depression-like behavior were still observed 8 days after cessation of the final social defeat session. These results suggest that repeated social defeat stress induces a chronic hyperthermia in rats that is associated with behavior resembling depression.

为了更好地了解在社会心理压力情况下发生持续性低热的患者，我们旨在建立一种压力诱导的慢性低热（高热）动物模型。我们测量核心体温（Tc）雄性Wistar大鼠后，他们受到4个社会失败的时期（每个时期包括7个每天1小时的压力暴露在光周期，然后是无压力的一天）。在4个社交失败期后，应激大鼠在光照和黑暗期均显示出较小但显著高于对照大鼠的Tc（+0.2-0.3℃）。他们还表现出类似抑郁症的行为。在最后一次社交失败会议停止后8天，仍然观察到体温过高和抑郁样行为。这些结果表明，反复的社会失败压力诱导大鼠慢性体温过高，这与类似抑郁的行为有关。