Effect of central nervous system on small intestinal cell growth And apoptosis

点击翻译按钮获取中文摘要

The aim of this study is to examine if the hypothalamus, central nervous system, regulates mucosal cell growth and apoptosis in the small intestine. Epithelial homeostasis is balanced by regulation of cell proliferation and cell death.Intestinal mucosal apoptosis decreased by the ventromedial hypothalamus lesions,which induced hyperphagia and obesity. In contrast, sustained anorexia induced by administration of anorectic agents increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to regulation of mucosal homeostasis in the intestinal mucosa.