Effect of central nervous system on small intestinal cell growth And apoptosis

中枢神经系统对小肠细胞生长和凋亡的影响

• 批准号: 20590728
• 负责人: KAZUMA Fujimoto
• 金额: $ 2.33万
• 依托单位: Saga University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590728/
• 关键词: 視床下部; 食欲; 代謝調節; 消化吸収; 小腸粘膜増殖; 生理作用; 迷走神経; メタボリック症候群; 生活習慣; 中枢神経; 小腸; 粘膜; 増殖機構; アポトーシス; 摂食中枢; 満腹中枢; アミン類; 糖類; レプチン; グレリン; 小腸培養

The aim of this study is to examine if the hypothalamus, central nervous system, regulates mucosal cell growth and apoptosis in the small intestine. Epithelial homeostasis is balanced by regulation of cell proliferation and cell death.Intestinal mucosal apoptosis decreased by the ventromedial hypothalamus lesions,which induced hyperphagia and obesity. In contrast, sustained anorexia induced by administration of anorectic agents increased intestinal apoptosis. These results indicate that the central nervous system, in addition to local factors, is related to regulation of mucosal homeostasis in the intestinal mucosa.

本研究的目的是检查下丘脑（中枢神经系统）是否调节小肠粘膜细胞的生长和凋亡。通过调节细胞增殖和细胞死亡来平衡上皮稳态。下丘脑腹内侧病变导致肠粘膜细胞凋亡减少，从而诱发食欲过盛和肥胖。相反，施用厌食剂引起的持续厌食会增加肠道细胞凋亡。这些结果表明，中枢神经系统除了局部因素外，还与肠粘膜内稳态的调节有关。

项目成果

Hepatitis C virus infection enhances insulin resistance induced by visceral fat accumulation

• DOI: 10.1111/j.1478-3231.2008.01853.x
• 发表时间: 2009-02-01
• 期刊: LIVER INTERNATIONAL
• 影响因子: 6.7
• 作者: Eguchi, Yuichiro;Mizuta, Toshihiko;Fujimoto, Kazuma
• 通讯作者: Fujimoto, Kazuma

消化器臓器における幹細胞研究の進歩 : In vivo analysis of intestinal stem cells

消化器官干细胞研究进展：肠道干细胞的体内分析

• 发表时间: 2009
• 作者: 大谷顕史;藤本一眞;Kuo K.
• 通讯作者: Kuo K.

Post-allenge hyperglycemia is a significant risk factor for the development of hepatocellular carcinoma in patients with chronic hepatitis C.

过敏后高血糖是慢性丙型肝炎患者发生肝细胞癌的重要危险因素。

• 发表时间: 2011
• 期刊: J Gastroenterol. [Epub ahead of print]
• 作者: Takahashi H;Mizuta T;Eguchi Y;Kawaguchi Y;Kuwashiro T;Oeda S;Isoda H;Oza N;Iwane S;Izumi K;Anzai K;Ozaki I;Fujimoto K.
• 通讯作者: Fujimoto K.

Recapitulation of the Wnt-dependent intestinal stem cell niche in long-term culture

长期培养中 Wnt 依赖性肠道干细胞生态位的重现

• 发表时间: 2008
• 作者: 大谷顕史;藤本一眞;Calvin Kuo.
• 通讯作者: Calvin Kuo.

In : Olives and Olive Oil in Health and Disease Prevention(Azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling and the effects of the olive oil.)(edited by Preedy VR and Watson RR.)

摘自：橄榄和橄榄油在健康和疾病预防中的作用（氧化偶氮甲烷通过 Wnt/β-连环蛋白信号传导诱导结肠癌以及橄榄油的作用。）（由 Preedy VR 和 Watson RR 编辑。）

• 发表时间: 2010
• 作者: Fujise T;Iwakiri R;Shiraishi R;Fujimoto K
• 通讯作者: Fujimoto K