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Study of molecular basis of motilin and growth hormone secretagogue receptors

Study of molecular basis of motilin and growth hormone secretagogue receptors
胃动素和生长激素促分泌受体的分子基础研究
批准号:
20590727
负责人:
MATSUURA Bunzo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor and GHS receptor. We have identified new critical residues in the transmembrane domains of the motilin receptor for erythromycin binding and activity using receptor mutagenesis. We have also generated human motilin receptor transgenic mice, and clarified relationship between motilin receptor and GHS receptor.
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会议论文
Mutational analysis of the predicted intracellular loop domains of the humanmotilin receptor.
预测的人胃动素受体细胞内环结构域的突变分析。
DOI: --
发表时间: 2008
期刊: Am J Physiol-Gastrointest Liver Physiol 294
影响因子: --
作者: [Tokunaga H, Matsuura B, Dong, M, Miller LJ, Ueda T, Furukawa S, Hiasa Y, Onji M]
通讯作者: Onji M
Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol(ME3738)through enhancing interferon-beta.
22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) 通过增强干扰素-β 来抑制丙型肝炎病毒复制。
DOI: --
发表时间: 2008
期刊: Hepatology 48
影响因子: --
作者: [Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Yamashita N, Matsuura B, Michitaka K, Chung RT, Onji M]
通讯作者: Onji M
DOI: 10.1111/j.1872-034x.2009.00614.x
发表时间: 2010-04-01
期刊: HEPATOLOGY RESEARCH
影响因子: 4.2
作者: [Michitaka, Kojiro, Hiraoka, Atsushi, Onji, Morikazu]
通讯作者: Onji, Morikazu
DOI: 10.1016/j.regpep.2010.08.002
发表时间: 2011-01
期刊: Regulatory Peptides
影响因子: --
作者: [T. Ueda;B. Matsuura;T. Miyake;S. Furukawa;M. Abe;Y. Hiasa;M. Onji]
通讯作者: T. Ueda;B. Matsuura;T. Miyake;S. Furukawa;M. Abe;Y. Hiasa;M. Onji
30
    To explore the molecular basis of ligand binding and receptor activation of human motlin receptor
    • 批准号:
      18590683
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.41万
    • 财政年份:
      2006
    • 负责人:
      MATSUURA Bunzo
    • 依托单位:
    To explore the molecular basis of ligand binding and receptor activation of human motilin receptor
    • 批准号:
      16590599
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2004
    • 负责人:
      MATSUURA Bunzo
    • 依托单位:
    海外基金