Study of molecular basis of motilin and growth hormone secretagogue receptors
Study of molecular basis of motilin and growth hormone secretagogue receptors
批准号:
20590727
负责人:
MATSUURA Bunzo
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor and GHS receptor. We have identified new critical residues in the transmembrane domains of the motilin receptor for erythromycin binding and activity using receptor mutagenesis. We have also generated human motilin receptor transgenic mice, and clarified relationship between motilin receptor and GHS receptor.
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Mutational analysis of the predicted intracellular loop domains of the humanmotilin receptor.
预测的人胃动素受体细胞内环结构域的突变分析。
DOI:
--
发表时间:
2008
期刊:
Am J Physiol-Gastrointest Liver Physiol 294
影响因子:
--
作者:
[Tokunaga H, Matsuura B, Dong, M, Miller LJ, Ueda T, Furukawa S, Hiasa Y, Onji M]
通讯作者:
Onji M
Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol(ME3738)through enhancing interferon-beta.
22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) 通过增强干扰素-β 来抑制丙型肝炎病毒复制。
DOI:
--
发表时间:
2008
期刊:
Hepatology 48
影响因子:
--
作者:
[Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Yamashita N, Matsuura B, Michitaka K, Chung RT, Onji M]
通讯作者:
Onji M
DOI:
10.1111/j.1872-034x.2009.00614.x
发表时间:
2010-04-01
期刊:
HEPATOLOGY RESEARCH
影响因子:
4.2
作者:
[Michitaka, Kojiro, Hiraoka, Atsushi, Onji, Morikazu]
通讯作者:
Onji, Morikazu
DOI:
10.1016/j.regpep.2010.08.002
发表时间:
2011-01
期刊:
Regulatory Peptides
影响因子:
--
作者:
[T. Ueda;B. Matsuura;T. Miyake;S. Furukawa;M. Abe;Y. Hiasa;M. Onji]
通讯作者:
T. Ueda;B. Matsuura;T. Miyake;S. Furukawa;M. Abe;Y. Hiasa;M. Onji
消化管運動促進物質モチリン・エリスロマイシンのモチリン受容体におけるシグナル伝達系の解析
促胃肠动力物质胃动素和红霉素胃动素受体信号转导系统分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[松浦文三, 上田晃久, 恩地森一]
通讯作者:
恩地森一
共 30 条
To explore the molecular basis of ligand binding and receptor activation of human motlin receptor
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批准号:18590683
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.41万
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财政年份:2006
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负责人:MATSUURA Bunzo
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依托单位:
To explore the molecular basis of ligand binding and receptor activation of human motilin receptor
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批准号:16590599
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:MATSUURA Bunzo
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依托单位:
海外基金