Role of REG protein in the regeneration and carcinogenesis of colorectal epithelial cells

REG蛋白在结直肠上皮细胞再生及癌变中的作用

• 批准号: 20590747
• 负责人: FUKUI Hirokazu
• 金额: $ 2.91万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590747/
• 关键词: 遺伝子; 癌; 再生医学; 病理学; 臨床

REG protein is induced by Interleukins 6 and 22 stimulations in colitis tissues. REG protein has an anti-apoptotic effect on colonic epithelial cells and its effect may play a role in the development of inflammation-related cancers. REG protein is overexpressed in the dysplastic lesion in ulcerative colitis tissues, and therefore, its detection may be an useful tool to not only diagnose but also predict ulcerative colitis-related neoplastic lesions.

REG 蛋白由结肠炎组织中的白细胞介素 6 和 22 刺激诱导。 REG蛋白对结肠上皮细胞具有抗凋亡作用，其作用可能在炎症相关癌症的发生发展中发挥作用。 REG蛋白在溃疡性结肠炎组织的发育异常病变中过度表达，因此，其检测不仅可以作为诊断而且可以预测溃疡性结肠炎相关肿瘤病变的有用工具。

项目成果

Expression of SDF-1 and nuclear CX predict lymph node metastasis in colorectal cancer.

SDF-1和核CX的表达预测结直肠癌的淋巴结转移。

• 发表时间: 2008
• 期刊: Br J Cancer 98
• 作者: Yoshitake N;Fukui H;Yamagishi H;Sekikawa A;Fujii S;Tomita S;Ichikawa K;Imura J;Hiraishi H;Fujimori T
• 通讯作者: Fujimori T

Role of Necl-5 in the Pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulfate.

Necl-5 在二甲肼和/或葡聚糖硫酸钠诱导的结直肠病变病理生理学中的作用。

• 发表时间: 2009
• 期刊: J Pathol 217
• 作者: Abe A;Fukui H;Fujimori T
• 通讯作者: Fujimori T

REG Ia protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells

REG Ia 蛋白介导胃癌细胞中 STAT3 信号传导的抗凋亡作用

• 发表时间: 2008
• 期刊: Carcinogenesis 29
• 作者: Idogawa M;et al;白石良介;Sekikawa A
• 通讯作者: Sekikawa A

Expression of SDF-la and nuclear CXCR4 predict lymph node metastasis in colorectal cancer

SDF-la和核CXCR4的表达预测结直肠癌淋巴结转移

• 发表时间: 2008
• 期刊: Br J Cancer 98
• 作者: 鬼沢道夫;永石宇司;ほか;藤谷幹浩,上野伸展,瀬川修一,奈田利恵,稲場勇平,盛一健太郎,小林直之,執行達郎,高後裕;Yoshitake N
• 通讯作者: Yoshitake N

Immunohistochemical Analysis of REG Iα Expression in Ulcerative Colitis-Associated Neoplastic Lesions

• DOI: 10.1159/000321808
• 发表时间: 2011-01-01
• 期刊: DIGESTION
• 影响因子: 3.2
• 作者: Tanaka, Hiroyuki;Fukui, Hirokazu;Fujimori, Takahiro
• 通讯作者: Fujimori, Takahiro