Protective role of Reg protein on mucosal injury in the gastrointestinal tract

Reg蛋白对胃肠道黏膜损伤的保护作用

• 批准号: 23590929
• 负责人: FUKUI Hirokazu
• 金额: $ 3.41万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590929/
• 关键词: 遺伝子; 再生医学; 臨床; 感染; 癌

Reg protein may function as an antimicrobial peptide and its expression is significantly regulated by IL-22 stimulation. Furthermore, Reg protein functions a trophic and/or anti-apoptotic factor on not only epithelial but also endothelial cells in the gastrointestinal mucosa. These effects are advantageous to protect the gastrointestinal mucosal injury. However, in gastric cancer tissues the anti-apoptotic effect of dysregulated Reg protein may confer resistance to chemotherapeutic drugs in gastric cancer cells.

Reg蛋白可能作为一种抗菌肽发挥作用，其表达受IL-22刺激的显著调节。此外，Reg蛋白不仅在胃肠粘膜中的上皮细胞而且在内皮细胞上起营养和/或抗凋亡因子的作用。这些作用有利于保护胃肠道粘膜损伤。然而，在胃癌组织中，调节异常的Reg蛋白的抗凋亡作用可能赋予胃癌细胞对化疗药物的抗性。

项目成果

胃癌細胞の浸潤におけるインターロイキン22の役割について

白细胞介素22在胃癌细胞侵袭中的作用

• 发表时间: 2012
• 作者: Sun C;Fukui H;Fukui H;Fukui H;福井広一;Fukui H;福井広一
• 通讯作者: 福井広一

Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins

• DOI: 10.1152/ajpgi.00454.2011
• 发表时间: 2012-07-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
• 影响因子: 4.5
• 作者: Chen, Xin;Oshima, Tadayuki;Miwa, Hiroto
• 通讯作者: Miwa, Hiroto

DMBT1 Is a Novel Gene Induced by IL-22 in Ulcerative Colitis

• DOI: 10.1002/ibd.21473
• 发表时间: 2011-05-01
• 期刊: INFLAMMATORY BOWEL DISEASES
• 影响因子: 4.9
• 作者: Fukui, Hirokazu;Sekikawa, Akira;Fujimori, Takahiro
• 通讯作者: Fujimori, Takahiro

Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front.

• DOI: 10.1371/journal.pone.0074757
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Oshima T;Shan J;Okugawa T;Chen X;Hori K;Tomita T;Fukui H;Watari J;Miwa H
• 通讯作者: Miwa H

REG Ia plays a role in resistance to chemotherapy in gastric cancer

REG Ia 在胃癌化疗耐药中发挥作用

• 作者: Sun C;Fukui H;Shan Jin;Toshihiko Tomita;Tadayuki Oahima;Jiro Watari;Miwa H.;福井広一;福井広一;福井広一;福井広一;Fukui H
• 通讯作者: Fukui H