Establishment of cancer surveillance using serum anti-p53 antibody in patients with ulcerative colitis

使用溃疡性结肠炎患者血清抗 p53 抗体建立癌症监测

• 批准号: 20590748
• 负责人: IWAO Yasushi
• 金额: $ 2.91万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590748/
• 关键词: 潰瘍性大腸炎; 大腸癌; サーベイランス; ELISA; p53; dysplasia; 内神鏡; 早期発見; 清瘍性大腸炎; 内視鏡

Here we evaluated clinical usefulness of the measurement of anti-p53 antibodies (Abs) by enzyme-linked immunosorbent assay (ELISA) using sera samples from ulcerative colitis (UC) patients. Serum p53 Ab was positive in 15.0% of UC, while it was positive only in 1.6% of HCs. Eight of 13 (61.5%) UC patients with CRC or dysplasia were positive for serum p53 Abs. This study revealed that p53 Ab developed in the progression of UC-associated CRC but not in all patients with neoplasia, suggesting that it is helpful in salvaging patients who drop from a surveillance program.

在这里，我们评估的抗p53抗体（抗体）的测量酶联免疫吸附试验（ELISA）的溃疡性结肠炎（UC）患者的血清样本的临床实用性。p53 Ab在UC中的阳性率为15.0%，在HC中的阳性率为1.6%。13例UC伴结直肠癌或异型增生患者中8例（61.5%）p53抗体阳性。这项研究显示，p53抗体在UC相关CRC的进展中产生，但不是在所有肿瘤患者中产生，这表明它有助于挽救从监测计划中脱落的患者。

项目成果

A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis

• DOI: 10.1007/s00535-007-2129-6
• 发表时间: 2008-01-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Sakuraba, Atsushi;Sato, Toshiro;Hibi, Toshifumi
• 通讯作者: Hibi, Toshifumi

Efficacy of infliximab for induction and maintenance of remission in intestinal Behcet's disease

• DOI: 10.1002/ibd.20457
• 发表时间: 2008-09-01
• 期刊: INFLAMMATORY BOWEL DISEASES
• 影响因子: 4.9
• 作者: Naganuma, Makoto;Sakuraba, Atsushi;Hibi, Toshifumi
• 通讯作者: Hibi, Toshifumi

Rapid endoscopic improvement is important for 1-year avoidance of colectomy but not for the long-term prognosis in cyclosporine A treatment for ulcerative colitis

快速内镜检查改善对于 1 年内避免结肠切除术很重要，但对于环孢素 A 治疗溃疡性结肠炎的长期预后并不重要

• DOI: 10.1007/s00535-010-0273-x
• 发表时间: 2010
• 期刊: Journal of Gastroenterology
• 影响因子: 6.3
• 作者: Taku Kobayashi;M. Naganuma;S. Okamoto;T. Hisamatsu;N. Inoue;H. Ichikawa;T. Takayama;R. Saito;T. Sujino;H. Ogata;Y. Iwao;T. Hibi
• 通讯作者: T. Hibi

大腸腫瘍性病変に対するESDの工夫

结直肠肿瘤病变的 ESD 创新

• 发表时间: 2010
• 作者: 今枝博之;細江直樹;中溝裕雅;別所理恵子;齋藤理子;小池祐司;井上詠;石井良幸;長谷川博俊;岩男泰;緒方晴彦;北川雄光;日比紀文
• 通讯作者: 日比紀文

Oncogenic Smad3 Signaling Induced by Chronic Inflammation Is an Early Event in Ulcerative Colitis-associated Carcinogenesis

• DOI: 10.1002/ibd.21395
• 发表时间: 2011-03-01
• 期刊: INFLAMMATORY BOWEL DISEASES
• 影响因子: 4.9
• 作者: Kawamata, Seiji;Matsuzaki, Koichi;Okazaki, Kazuichi
• 通讯作者: Okazaki, Kazuichi