Research on voltage-gated Kv1,3 K^+ channel for the pathogenesis of autoimmune pancreatitis

为了确定可能导致自身免疫性胰腺炎的遗传因素，我们鉴定了由KCNA3调节的电压门控Kv1.3通道蛋白。我们调查了其在发病机制中的作用，但未发现显著相关性。通过全基因组关联研究，我们在14条染色体上发现了与自身免疫性胰腺炎易感性相关的25个候选基因。我们正在通过对这些基因内snp的精细定位来确认这种关联。

To identify genetic factors that might contribute to autoimmune pancreatitis, we identified the voltage-gated Kv1.3 channel protein regulated by KCNA3. We investigated its role in the pathogenesis, but found no significant association. Using genome wide association study, we found 25 candidate genes on 14 chromosomes, which are associated with susceptibility to autoimmune pancreatitis. We are confirming the association by fine mapping with SNPs within these genes.