Role and mechanism of thrombospondin in response to beta blocker therapy in patients with congestive heart failure
血小板反应蛋白在充血性心力衰竭患者β受体阻滞剂治疗中的作用和机制
基本信息
- 批准号:20590834
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We evaluated Ala523Thr polymorphism(G/A) and thrombospondin-1 plasma levels in nonischemic congestive heart failure patients before, 6, and 12 months after administration of beta blocker therapy and in normal healthy volunteers. There were no significant differences of thrombospondin-1 plasma levels between GG group and non GG group in normal healthy volunteers. No significant differences of thrombospondin-1 plasma levels were found between GG group and non GG group in nonischemic congestive heart failure patients. There were significant correlations between changes in BNP levels from before to 12 months after administration of beta blocker therapy and those in plasma thrombospondin-1 levels. Thrombospondin-1 may play a role in hemodynamic optimization at the chronic stage of nonischemic congestive heart failure.
我们评估了Ala 523 Thr多态性(G/A)和血小板反应蛋白-1血浆水平在非缺血性充血性心力衰竭患者前,6个月,12个月后,β受体阻滞剂治疗和正常健康志愿者。正常健康志愿者血浆凝血酶敏感蛋白-1水平在GG组和非GG组之间无显著性差异。非缺血性充血性心力衰竭患者血浆凝血酶敏感蛋白-1水平在GG组和非GG组之间无显著性差异。从β受体阻滞剂治疗前到治疗后12个月BNP水平的变化与血浆血小板反应蛋白-1水平的变化之间存在显著相关性。血小板反应蛋白-1可能在非缺血性充血性心力衰竭慢性期血流动力学优化中发挥作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Beneficial effect of taurine treatment against doxorubicin-induced cardiotoxicity in mice.
- DOI:10.1007/978-0-387-75681-3_7
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Takashi Ito;Satoko Muraoka;Kyoko Takahashi;Y. Fujio;S. Schaffer;J. Azuma
- 通讯作者:Takashi Ito;Satoko Muraoka;Kyoko Takahashi;Y. Fujio;S. Schaffer;J. Azuma
The effect of low-dose pergolide on the valves of the heart in Japanese patients
小剂量培高利特对日本患者心脏瓣膜的影响
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Kouno;Y.;Takemoto;Y.;Yoshiyama;M.
- 通讯作者:M.
Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy
去甲肾上腺素转运蛋白和肾上腺素受体α1D的多态性与扩张型心肌病对β受体阻滞剂的反应相关
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:2.8
- 作者:Nonen;S.;Fujio;Y.;Takemoto;Y.;Yoshiyama;M.;Azuma;J.
- 通讯作者:J.
The effect of low-dose pergolide on the valves of the heart in Japannese patients
小剂量培高利特对日本患者心脏瓣膜的影响
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Imanishi T;et al.;Yasushi Kouno
- 通讯作者:Yasushi Kouno
Determination of regurgitant orifice area with the use of a new three-dimensional flow convergence geometric assumption in functional mitral requrqitation
在功能性二尖瓣反流中使用新的三维血流收敛几何假设确定反流口面积
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Kubo T;Imanishi T;et al.;Yoshiki Matsumura
- 通讯作者:Yoshiki Matsumura
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TAKEMOTO Yasuhiko其他文献
TAKEMOTO Yasuhiko的其他文献
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{{ truncateString('TAKEMOTO Yasuhiko', 18)}}的其他基金
The rationalization and optimization of distribution systems based on mechanism design in supply chain environments
供应链环境下基于机制设计的分销系统合理化与优化
- 批准号:
26350433 - 财政年份:2014
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Role of thrombospondin and nicotine dependence in vascular damage from smoking
血小板反应蛋白和尼古丁依赖性在吸烟引起的血管损伤中的作用
- 批准号:
23591056 - 财政年份:2011
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Ripple effect of quality issues on supply chain and its solutions
质量问题对供应链的连锁反应及其解决方案
- 批准号:
21710156 - 财政年份:2009
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
A study on approach to quality assurance based on reliability engineering
基于可靠性工程的质量保证方法研究
- 批准号:
18710136 - 财政年份:2006
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Young Scientists (B)