A role of CX3CL1/CX3CR1 in atherosclerosis

CX3CL1/CX3CR1在动脉粥样硬化中的作用

• 批准号: 20590850
• 负责人: TANAKA Seiya
• 金额: $ 2.58万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590850/
• 关键词: 冠動脈疾患; PCI; ケモカイン; 再狭窄; プラーク破裂; 冠動脈ステント留置術; 血管内エコー; IB-IVUS; 冠動脈プラーク破裂; サイトカイン; 動脈硬化

The cause of rupture of atherosclerotic site in vasculature, which trigger unstable angina and myocardial infarction, is not elucidated yet. In this research we found that CX3CL1, one of protein which induce inflammation, was elevated immediately after injuring atherosclerotic site and maintained the level at least 12-hour. And it was more elevated with more lipid-rich atherosclerotic site. It is suggested that plasma CX3CL1 might be a diagnostic marker of unstable angina and myocardial infarction.

引起不稳定型心绞痛和心肌梗死的血管粥样硬化部位破裂的原因尚不清楚。本研究发现，诱导炎症的蛋白之一CX3CL1在动脉粥样硬化部位损伤后立即升高，并维持至少12小时。脂质丰富的动脉粥样硬化部位越多，它就越高。提示血浆CX3CL1可作为不稳定型心绞痛和心肌梗死的诊断指标。

项目成果

Early elevation of Fractalkine(CX3CL1) after percutaneous coronary implantation

经皮冠状动脉植入后Fractalkine（CX3CL1）早期升高

• 发表时间: 2010
• 作者: Seiya Tanaka;Yoshitaka Muraoka;Yuki Tsuda;Shinjyo Sonoda;Masahiro Okazaki;Yutaka Otsuji;田中正哉
• 通讯作者: 田中正哉

Early elevation of Fractalkine(CX3CL1) afterpercutaneous coronary implantation

经皮冠状动脉植入后Fractalkine(CX3CL1)早期升高

• 发表时间: 2010
• 作者: Seiya Tanaka;Yoshitaka Muraoka;Yuki Tsuda;Shinjyo Sonoda;Masahiro Okazaki;Yutaka Otsuji
• 通讯作者: Yutaka Otsuji

Early elevation of Fractalkine(CX3CL1)after coronary stent implantation

冠状动脉支架植入后Fractalkine(CX3CL1)早期升高

• 发表时间: 2010
• 作者: Seiya Tanaka;Yoshitaka Muraoka;Yuki Tsuda;Shinjyo Sonoda;Masahiro Okazaki;Yutaka Otsuji;田中正哉
• 通讯作者: 田中正哉